This Is MS Multiple Sclerosis Knowledge & Support Community

Identifying Microvascular Differences in Multiple Sclerosis via Optical Coherence Tomography Angiography (OCT-A)

https://iovs.arvojournals.org/article.a ... id=2768711

Conclusions :

Curated OCT-A and macular vessel density data suggests microvascular differences in MS patient groups compared to healthy controls. This is indicative of a potential relationship between ophthalmic microvascular changes and MS severity.

Further statistical analysis will help to highlight the significance of these early findings. Preliminary data further suggests that specific regions of the macula may be particularly affected by MS.

Future research investigating microvascular biomarkers on OCT-A imaging may enable ophthalmologists and neurologists to better care for MS patients and preserve eye function.

Characterization of Retinal vascular changes in Multiple Sclerosis using Adaptive Optics and OCTA

https://iovs.arvojournals.org/article.a ... id=2768856

Conclusions

AO-SLO (Adaptive optics scanning laser ophthalmoscopy) demonstrates focal retinal vessel changes in living human MS eyes without history of optic neuritis. These may correspond with microscopic retinal vascular changes previously observed in post-mortem samples.

Periphlebitis, a qualitative retinal vascular changes on clinical exam and retinal vessel density (RVD) decreased on OCTA have been observed in people with multiple sclerosis (MS). Focal microscopic changes in both inflamed and non-inflamed retinal vessels have been observed postmortem.

Adaptive optics scanning laser ophthalmoscopy (AO-SLO) facilitates viewing of the in vivo human retina with microscopic resolution and has not been widely applied in MS.

Novel microscopic foveal pit pathology in multiple sclerosis revealed with adaptive optics ophthalmoscopy

https://iovs.arvojournals.org/article.a ... id=2769442

Conclusions :

Previously unreported microscopic features, not detectable with clinical examination, were observed in the foveal pit of 5 out of 7 MS subjects. Monitoring these structures may be useful as a biomarker for evaluating ocular disease progression in MS.

Interesting study! 5 out of 7 subjects with MS had this, that's a high percentage (71.4 percent). Even though a very small sample size. Hopefully they'll follow up with a larger study. Thanks for posting this study.

ThisIsMA wrote: ↑Tue Jun 16, 2020 8:55 am Interesting study! 5 out of 7 subjects with MS had this, that's a high percentage (71.4 percent). Even though a very small sample size. Hopefully they'll follow up with a larger study. Thanks for posting this study.

Yes. It is something that could yield new information