The lancet. Open call for using NFL in diagnosis and monitoring
Posted: Thu Jun 25, 2020 1:26 am
Neurofilament light in blood. What more is needed for clinical implementation?
https://www.thelancet.com/pdfs/journals ... 0201-2.pdf
Cerebrospinalfluid (CSF) neurofilament light (NfL) is the best established fluid biomarker for neuroaxonal injury, irrespective of the underlying cause.
It has been studied as a disease intensity marker in both relapsing-remitting and progressive multiple sclerosis(MS), and its concentration often normalises in response to successful disease-modifying treatment.
Novel ultrasensitive analytical technologies have allowed for the reliable measurement of NfL concentration in blood; virtually all findings for CSF NfL have been replicated in blood, and CSF and blood NfL concentrations show similar dynamics over time in response to acute injury and may thus be used interchangeably
[...]
https://www.thelancet.com/pdfs/journals ... 0201-2.pdf
Cerebrospinalfluid (CSF) neurofilament light (NfL) is the best established fluid biomarker for neuroaxonal injury, irrespective of the underlying cause.
It has been studied as a disease intensity marker in both relapsing-remitting and progressive multiple sclerosis(MS), and its concentration often normalises in response to successful disease-modifying treatment.
Novel ultrasensitive analytical technologies have allowed for the reliable measurement of NfL concentration in blood; virtually all findings for CSF NfL have been replicated in blood, and CSF and blood NfL concentrations show similar dynamics over time in response to acute injury and may thus be used interchangeably
[...]