PET differentiates pathological variants of MS
Posted: Thu Aug 20, 2020 11:46 pm
TSPO PET With 18F-GE-180 to Differentiate Variants of Multiple Sclerosis
Relapsing-Remitting Multiple Sclerosis, Tumefactive Demyelination, and Baló’s Concentric Sclerosis
https://journals.lww.com/nuclearmed/Abs ... 96521.aspx
Abstract
PET targeting the translocator protein (TSPO) expression is an interesting approach to detect neuroinflammation, as TSPO is upregulated in activated macrophages and microglia.
Considering the variable pathophysiology of multiple sclerosis (MS) variants, we compare TSPO PET using 18F-GE-180 in 3 different demyelinating diseases of the central nervous system: relapsing-remitting MS, tumefactive MS, and Baló’s concentric sclerosis.
Visualization of neuroinflammation and its PET patterns in addition to MRI may contribute to accurate distinction and monitoring of central nervous system demyelination.
Relapsing-Remitting Multiple Sclerosis, Tumefactive Demyelination, and Baló’s Concentric Sclerosis
https://journals.lww.com/nuclearmed/Abs ... 96521.aspx
Abstract
PET targeting the translocator protein (TSPO) expression is an interesting approach to detect neuroinflammation, as TSPO is upregulated in activated macrophages and microglia.
Considering the variable pathophysiology of multiple sclerosis (MS) variants, we compare TSPO PET using 18F-GE-180 in 3 different demyelinating diseases of the central nervous system: relapsing-remitting MS, tumefactive MS, and Baló’s concentric sclerosis.
Visualization of neuroinflammation and its PET patterns in addition to MRI may contribute to accurate distinction and monitoring of central nervous system demyelination.