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i've been doing some reading re 2:16alphahydroxyestrone ratios in health and disease. interesting info at this link, but i'm still very early in this learning curve...
Sex Steroids and Immunity
Sex Hormones and Immune Function
Hormones and Cytokines
Hormonal Effects on Immune System
Breast Cancer
>2-Hydroxyestrone/16-Hydroxyestrone Ratio
Gender and Age in Lupus
... Results One year of treatment with testosterone gel was associated with improvement in cognitive performance (P = .008) and a slowing of brain atrophy (P <.001). There was no significant effect of testosterone treatment on gadolinium-enhancing lesion numbers (P = .31) or volumes (P = .94). Lean body mass (muscle mass) was increased (P = .02).
Conclusion These exploratory findings suggest that testosterone treatment is safe and well tolerated and has potential neuroprotective effects in men with relapsing-remitting MS.
women's sex hormones and ms
Posted: Sun May 09, 2021 6:33 am
by jimmylegs
the section snippets thing is kind of weird, but interesting content for what's there:
"...Serum lipid profile is associated with protective effects of OC use on disability of RRMS patients. Lipoprotein metabolism may be involved in the modulatory effects of sex steroids on the severity of the disease."
Testosterone therapy has proven effective in relieving andropausal symptoms, usually within three to six weeks’ time. ...
It is important to realize that changes in libido, increased fatigue and decreased physical agility are also symptoms of MS. For that reason, a diagnosis of andropause may be overlooked. After your next blood work and physical exam, ask your doctor if you might be a suitable candidate for testosterone replacement.
"... Systemic HT use was associated with better physical QOL in postmenopausal women with MS in this observational study. Further studies are necessary to investigate causality."
"The prevalence of multiple sclerosis (MS) increases significantly with decreasing UV B light exposure, possibly reflecting a
protective effect of vitamin D3. ... The intact, vitamin D3-fed female mice had significantly less clinical, histopathological, and immunological signs of EAE than ovariectomized females or intact or castrated males. Correlating with reduced EAE, the intact, vitamin D3-fed female mice had significantly more 1,25-dihydroxyvitamin D3 and fewer CYP24A1 transcripts, encoding the 1,25-dihydroxyvitamin D3-inactivating enzyme, in the spinal cord than the other groups of mice. Thus, there was an unexpected synergy between vitamin D3 and ovarian tissue with regard to EAE inhibition. ... If humans have a similar gender difference in vitamin D3 metabolism in the CNS, then sunlight deprivation would increase the MS risk more significantly in women than in men, which may contribute to the unexplained higher MS incidence in women than in men..."
"... Together, these findings suggest that there are gender differences in the CNS of MS patients that may affect lesion pathogenesis, that is, in males, estrogen synthesis and signaling are induced; whereas in females, progestogen synthesis and signaling are induced. These differences may represent contributing factors to gender differences in the prevalence and course of MS."
Re: SeXX Matters in Multiple Sclerosis
Posted: Thu Jun 17, 2021 4:30 am
by Jaded
jimmylegs wrote: ↑Sun May 09, 2021 6:36 am
haven't read this one yet, just browsing...