MS, HERVs and Covid 19?
Posted: Sun May 09, 2021 8:54 am
Greetings:
What does this research imply for MS patients?
https://secure.jbs.elsevierhealth.com/a ... 2Fjournals
Evidence of the pathogenic HERV-W envelope expression in T lymphocytes in association with the respiratory outcome of COVID-19 patients - EBioMedicine (thelancet.com)
Human Endogenous Retroviruses (HERVs) have been described as genetic elements present in the human genome. Their activation has increasingly been found to be associated with various diseases including cancer, multiple sclerosis, type 1 diabetes, and rheumatoid arthritis, which are all underlying diseases in patients developing severe forms of COVID-19. Several studies confirmed that the immunopathogenic envelope protein of HERV family W (HERV-W ENV) is involved in inflammatory and neurological diseases. Moreover, HERV-W was shown to be directly activated by exogenous viruses with various outcomes depending on triggering viruses and susceptible cells or tissues.
Added value of this study
We demonstrate for the first time an elevated expression of the HERV-W ENV protein in the blood cells of COVID-19 patients compared to that of healthy donors and its correlation with markers of inflammation including cytokines expression, and T cell differentiation and exhaustion, thus proposing its role in predicting the outcome of the disease. Based on the potential early reactivation by SARS-CoV-2, we propose HERV-W ENV protein as a contributing factor to the immunopathology of COVID-19.
Implications of all the available evidence
The identification of the association between HERV-W ENV expression and inflammatory and immune dysfunction in COVID-19 opens an avenue for further investigation of its role as a trigger of detrimental immune response.
Thanks, Vesta
What does this research imply for MS patients?
https://secure.jbs.elsevierhealth.com/a ... 2Fjournals
Evidence of the pathogenic HERV-W envelope expression in T lymphocytes in association with the respiratory outcome of COVID-19 patients - EBioMedicine (thelancet.com)
Human Endogenous Retroviruses (HERVs) have been described as genetic elements present in the human genome. Their activation has increasingly been found to be associated with various diseases including cancer, multiple sclerosis, type 1 diabetes, and rheumatoid arthritis, which are all underlying diseases in patients developing severe forms of COVID-19. Several studies confirmed that the immunopathogenic envelope protein of HERV family W (HERV-W ENV) is involved in inflammatory and neurological diseases. Moreover, HERV-W was shown to be directly activated by exogenous viruses with various outcomes depending on triggering viruses and susceptible cells or tissues.
Added value of this study
We demonstrate for the first time an elevated expression of the HERV-W ENV protein in the blood cells of COVID-19 patients compared to that of healthy donors and its correlation with markers of inflammation including cytokines expression, and T cell differentiation and exhaustion, thus proposing its role in predicting the outcome of the disease. Based on the potential early reactivation by SARS-CoV-2, we propose HERV-W ENV protein as a contributing factor to the immunopathology of COVID-19.
Implications of all the available evidence
The identification of the association between HERV-W ENV expression and inflammatory and immune dysfunction in COVID-19 opens an avenue for further investigation of its role as a trigger of detrimental immune response.
Thanks, Vesta