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not just for the xx cohort

Posted: Sun Dec 12, 2021 9:20 am
by jimmylegs
17β-estradiol and progesterone prevent cuprizone provoked demyelination of corpus callosum in male mice (2008)
https://onlinelibrary.wiley.com/doi/abs ... glia.20806

i'm still not sure about this cuprizone model, why copper depletion demyelination is considered equivalent for study purposes. am working through a few related thoughts on the matter, still have more reading to do.
in the meantime, more fun with hormones :)

Re: not just for the xx cohort

Posted: Sun Dec 12, 2021 1:40 pm
by NHE
jimmylegs wrote: Sun Dec 12, 2021 9:20 ami'm still not sure about this cuprizone model, why copper depletion demyelination is considered equivalent for study purposes. am working through a few related thoughts on the matter, still have more reading to do.
I have similar questions. Here’s a post on cuprizone with some links to papers.

viewtopic.php?t=31937