Innate immune activity increases over time in PPMS/SPMS
Posted: Tue Jan 25, 2022 10:56 am
Longitudinal change in TSPO PET imaging in progressive multiple sclerosis
https://onlinelibrary.wiley.com/doi/ful ... acn3.51431
Abstract
The objective of this pilot study was to assess a 2-year change in innate immune burden in 15 progressive multiple sclerosis (MS) patients using PK11195-PET.
Sixteen age-matched healthy controls (HC) were included for baseline comparison. PK11195 uptake was higher in MS patients compared to HC within normal-appearing white matter (NAWM) and multiple gray matter regions. In patients, PK11195 uptake increased in NAWM (p = 0.01), cortex (p = 0.04), thalamus (p = 0.04), and putamen (p = 0.02) at 12 months. Among patients remaining at 24 months, there was no further increase in PK11195.
Our data suggest that innate immune activity may increase over time in patients with progressive MS.
https://onlinelibrary.wiley.com/doi/ful ... acn3.51431
Abstract
The objective of this pilot study was to assess a 2-year change in innate immune burden in 15 progressive multiple sclerosis (MS) patients using PK11195-PET.
Sixteen age-matched healthy controls (HC) were included for baseline comparison. PK11195 uptake was higher in MS patients compared to HC within normal-appearing white matter (NAWM) and multiple gray matter regions. In patients, PK11195 uptake increased in NAWM (p = 0.01), cortex (p = 0.04), thalamus (p = 0.04), and putamen (p = 0.02) at 12 months. Among patients remaining at 24 months, there was no further increase in PK11195.
Our data suggest that innate immune activity may increase over time in patients with progressive MS.