Possibility of strengthening the BBB (poster)
Posted: Mon Apr 25, 2022 12:08 am
New treatment for multiple sclerosis could halt disease progression without weakening immune system
https://scholarsarchive.byu.edu/cgi/vie ... sters_2022
Additional Information
Dual Chimera claudin proteins have been shown to increase tight junction (TJ) strength.
We can use this protein to prove our ability to diminish paracellular transport of immune cells in vitro using trans well inserts. In our case we will start with CD4+ T cells because they have been found in active MS lesions
https://scholarsarchive.byu.edu/cgi/vie ... sters_2022
Additional Information
Dual Chimera claudin proteins have been shown to increase tight junction (TJ) strength.
We can use this protein to prove our ability to diminish paracellular transport of immune cells in vitro using trans well inserts. In our case we will start with CD4+ T cells because they have been found in active MS lesions