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Posted: **Fri Jun 03, 2022 3:35 am**

Biomarker panel increases accuracy for identification of an MS relapse beyond sNfL

https://www.sciencedirect.com/science/a ... 4822004333

Highlights

• Large-scale proteomics reveal serum markers associated with ongoing relapse in MS.
• Steroids alter serum proteins and must be considered for biomarker discovery.
• A 4-biomarker panel is more accurate at identifying relapse compared to sNfL only.

Posted: **Fri Jun 03, 2022 7:55 am**

Conclusion:
Our studies confirmed that sNfL is elevated during relapses in RRMS patients. Furthermore, we identified three other blood proteins, uPA, hK8 and DSG3 that were altered during relapse. Together, these four biomarkers could be used to monitor disease activity in RRMS patients.

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Biomarker panel increases accuracy for identification of an MS relapse

Biomarker panel increases accuracy for identification of an MS relapse

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