Ibudilast works for PPMS but not for SPMS

[frodo]

Effects of Ibudilast on Retinal Atrophy in Progressive Multiple Sclerosis Subtypes

https://n.neurology.org/content/early/2 ... 1.abstract

Discussion: Ibudilast treatment decreased GCIPL atrophy in PMS, driven by the PPMS cohort, with no effect seen in SPMS. Modulated atrophy of retinal layers may be detectable in sample sizes smaller than the SPRINT-MS trial and correlate with whole brain atrophy in PMS, further highlighting their utility as outcomes in PMS.

Classification of evidence: This study provides Class II evidence that ibudilast reduces composite ganglion cell and inner plexiform layer atrophy, without reduction of inner or outer nuclear layer atrophy, in patients with progressive MS but not those with secondary progressive MS.