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Bazedoxifene, an osteoporosis medicine for women, as Remyelinating agent
Posted: Tue Nov 28, 2023 12:07 pm
by DIM
Re: Bazedoxifene, an osteoporosis medicine for women, as Remyelinating agent
Posted: Wed Nov 29, 2023 6:24 am
by Jaded
Thanks DIM. As usual the trial is for those with relapsing remitting MS
Re: Bazedoxifene, an osteoporosis medicine for women, as Remyelinating agent
Posted: Wed Nov 29, 2023 7:25 am
by DIM
Jaded wrote: ↑Wed Nov 29, 2023 6:24 am
Thanks DIM. As usual the trial is for those with relapsing remitting MS
Unfortunately, although at this age most RRMS tend to become SPMS
Re: Bazedoxifene, an osteoporosis medicine for women, as Remyelinating agent
Posted: Sat Dec 02, 2023 8:23 am
by Jaded
I agree so I'm slightly baffled by the criteria!
Re: Bazedoxifene, an osteoporosis medicine for women, as Remyelinating agent
Posted: Sat Dec 02, 2023 5:32 pm
by ElliotB
Did you know that cholesterol is critical for myelin repair:
From Dr. Google:
Cholesterol made by neurons is crucial for repairing long-term damage to the myelin sheath. The myelin sheath is the fatty coating around nerve fibers that is damaged in multiple sclerosis (MS). Cholesterol synthesis in nerve cells ensures the replenishment of newly myelin-forming cells. When lesions develop in myelin disorders such as multiple sclerosis, the cholesterol- and lipid-rich insulating layer around the nerve fibres is lost. The finding suggests that increasing neuronal cholesterol synthesis may be helpful in treating MS.
Re: Bazedoxifene, an osteoporosis medicine for women, as Remyelinating agent
Posted: Sat Dec 02, 2023 5:36 pm
by ElliotB
From Dr. Google:
Common side effects of bazedoxifene and conjugated estrogens include:
Dizziness
Nausea
Stomach pain or discomfort
Diarrhea
Muscle spasm
Throat pain
Neck pain
Less common side effects include venous thromboembolism and deep vein thrombosis.
Re: Bazedoxifene, an osteoporosis medicine for women, as Remyelinating agent
Posted: Mon Dec 04, 2023 11:54 am
by DIM
ElliotB wrote: ↑Sat Dec 02, 2023 5:32 pm
Did you know that cholesterol is critical for myelin repair:
From Dr. Google:
Cholesterol made by neurons is crucial for repairing long-term damage to the myelin sheath. The myelin sheath is the fatty coating around nerve fibers that is damaged in multiple sclerosis (MS). Cholesterol synthesis in nerve cells ensures the replenishment of newly myelin-forming cells. When lesions develop in myelin disorders such as multiple sclerosis, the cholesterol- and lipid-rich insulating layer around the nerve fibres is lost. The finding suggests that increasing neuronal cholesterol synthesis may be helpful in treating MS.
Of course but I can't see the connection with the Bazedoxifene.
By the way Omega 3 esters (EPA+DHA) and CDP Choline are the best fat sources for myelin repair
Re: Bazedoxifene, an osteoporosis medicine for women, as Remyelinating agent
Posted: Wed Dec 06, 2023 3:06 pm
by Jaded
Hi DIM
Thanks - that's interesting. Haven't yet tried CDP Choline although I take Omega 3
Remyelination really would be the golden ticket for us
Re: Bazedoxifene, an osteoporosis medicine for women, as Remyelinating agent
Posted: Mon May 20, 2024 1:52 pm
by DIM
Selective Estrogen Receptor Modulator Enhances CNS Remyelination Independent of Estrogen Receptors (in vivo)
Free full text.
https://www.researchgate.net/publicatio ... _Receptors