obstruction of the glymphatic system
Posted: Sun Jan 14, 2024 11:51 pm
The dilated veins surrounding the cord in multiple sclerosis suggest elevated pressure and obstruction of the glymphatic system
https://www.sciencedirect.com/science/a ... 1924000120
Highlights
• There is dilatation of the bridging veins traversing the subarachnoid space surrounding both the brain and spinal cord in multiple sclerosis.
• The isolated enlargement of these veins suggests an alteration in impedance matching.
• Venous dilatation can obstruct the glymphatic pathway because of a shared outflow geometry of the two circulations and lead to an altered immune response.
Abstract
Recently, Clarke et al. published a study using spinal cord susceptibility weighted imaging in multiple sclerosis patients at 7T. They discovered dilated intradural extramedullary veins surrounding the cord.
The purpose of this commentary is to point out some recent research by our group, which suggests this dilatation also occurs in the bridging cortical veins surrounding the brain.
The dilatation indicates a focal elevation in the venous pressure secondary to impedance mismatching.
Due to the shared outflow geometry, dilatation of the outflow veins will obstruct the glymphatic pathway of the spinal cord altering the immune response.
https://www.sciencedirect.com/science/a ... 1924000120
Highlights
• There is dilatation of the bridging veins traversing the subarachnoid space surrounding both the brain and spinal cord in multiple sclerosis.
• The isolated enlargement of these veins suggests an alteration in impedance matching.
• Venous dilatation can obstruct the glymphatic pathway because of a shared outflow geometry of the two circulations and lead to an altered immune response.
Abstract
Recently, Clarke et al. published a study using spinal cord susceptibility weighted imaging in multiple sclerosis patients at 7T. They discovered dilated intradural extramedullary veins surrounding the cord.
The purpose of this commentary is to point out some recent research by our group, which suggests this dilatation also occurs in the bridging cortical veins surrounding the brain.
The dilatation indicates a focal elevation in the venous pressure secondary to impedance mismatching.
Due to the shared outflow geometry, dilatation of the outflow veins will obstruct the glymphatic pathway of the spinal cord altering the immune response.