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				Study: Status after discontinuation of Tysabri treatment
				Posted: Tue Nov 18, 2008 7:00 am
				by Frank
				RESULTS: 
With regard to clinical disease activity, neuroimaging, and immune responses, the majority of patients in our cohort were stable. Decreased lymphocyte cell numbers and altered cell ratios returned to normal 14 months after cessation of natalizumab. No infectious complications were observed.
Link
--Frank
 
			 
			
					
				Re: Study: Status after discontinuation of Tysabri treatment
				Posted: Tue Nov 18, 2008 8:34 am
				by HarryZ
				Frank wrote:RESULTS: 
With regard to clinical disease activity, neuroimaging, and immune responses, the majority of patients in our cohort were stable. Decreased lymphocyte cell numbers and altered cell ratios returned to normal 14 months after cessation of natalizumab. No infectious complications were observed.
Link
--Frank
 
Frank...thanks for that info. BTW, is there any data for the other patients who didn't fall into the stable category?  How long was your cohort on Tysabri and why did they stop using the drug?  Thanks.
Harry
 
			 
			
					
				
				Posted: Tue Nov 18, 2008 10:15 am
				by Frank
				Hi Harry, 
actually I have not been in any trial with Tysabri and I also dont know about any other publications on non stable patients. 
I suspended my Tysabri infusions in favour of giving ABX a try for a year. After completing my ABX experience i deceided to go back to Tysabri, so far Tysabri seems to work fine for me.
--Frank
			 
			
					
				
				Posted: Tue Nov 18, 2008 10:55 am
				by HarryZ
				Frank wrote:Hi Harry, 
actually I have not been in any trial with Tysabri and I also dont know about any other publications on non stable patients. 
I suspended my Tysabri infusions in favour of giving ABX a try for a year. After completing my ABX experience i deceided to go back to Tysabri, so far Tysabri seems to work fine for me.
--Frank
Hi Frank,
Thanks for the update.  That is one concern I have about Biogen....they don't tell us much if anything about the problem areas. Then again,  their marketing people are very careful about this and don't want to shed any possible light on anything that could restrict sales.
Glad to hear that Tysabri seems to be working fine for you. Keep us posted along the way.
Harry