Magnesium is natural potassium channel blocker.
Unlike Ampyra, which is a sustained-release version of a potassium channel blocking bird poison (fampridine), the body uses magnesium as it sees fit, and magnesium is used in hundreds of reactions in the body.
Magnesium is also a natural calcium-channel blocker, again, as the body sees fit. It is in the blocking of calcium's entry into the cells that magnesium is used to relax muscles.
A doctor once told me that people with MS are magnesium wasters, meaning their bodies excrete magnesium faster than normal, causing the body to become low in the Mg. The typical Mg lab test (serum Mg) is flawed in that the "normal" range at most labs is too low and because of the fact that the body tightly regulates the Mg in the blood (less than 1% of total body Mg); otherwise the heart would stop. So, in a living person, the serum Mg level will never be greatly
out of normal range, if at all. The body takes Mg from the bones and tissues to add to the blood, if needed. If the amount in the blood is starting
to get too high, the body will filter some of the Mg out with the kidneys.
The underestimated problem of using serum magnesium measurements to exclude magnesium deficiency in adults; a health warning is needed for "normal" results.
Personally, I have found magnesium (particularly topical Mg) to greatly reduce spasticity and tightness. These improvements (for me, at least) have been by no means a quick fix. But they are a true
fix, getting to the cause of the problem - low Mg. I am still learning and recently I have begun to learn of the need for proper, sufficient hydration in restoring Mg levels. http://organicconnectmag.com/mark-hyman-md-putting-magnesium-back-in-your-life/#.U19mA_ldV8E http://www.youtube.com/watch?v=GUWL1o2hSrs