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J Neuroimmunol. 2005 Aug;165(1-2):83-91. Related Articles, Links
Effective combination of minocycline and interferon-beta in a model of
Giuliani F, Fu SA, Metz LM, Yong VW.
Department of Clinical Neurosciences, University of Calgary, Calgary,
The objective of the current study was to investigate whether minocycline
improves the effect of an existing multiple sclerosis (MS) medication,
interferon-beta, on experimental autoimmune encephalomyelitis (EAE) in mice. When used
at sub-optimal doses, neither medication affected EAE but their combination at
these doses led to the significant alleviation of EAE disease severity scores
and histological outcomes. In culture, the toxicity of T cells to neurons was
alleviated by their prior exposure to minocycline or interferon-beta and their
combination further attenuated neuronal death. Collectively, these results
suggest the utility of the combination of minocycline and interferon-beta in MS.
PMID: 15958276 [PubMed - indexed for MEDLINE