This Is MS Multiple Sclerosis Community: Knowledge & Support

Pulse 17 ….. and now for something completely different

We made a small supplement change before Kim started this pulse. We removed one of two Chlorella tablets and replaced it with a 40,000 IU Serrapeptase cap. It is too early to link the character of the pulse with the change in sups, but it has me wondering. Kim was present the entire pulse. Meaning, she didn’t feel like there was this “other” person she was wearing on the outside that she wanted to get rid of. She’s been her normal, unrestrained, say what’s on her mind, animated self. Her walking has been pulse-like, but it’s also getting hot and humid outside; Washington got something like 16 inches of rain last week.

25-foot Walks – Faster than 5

All of the last 5 walks have been less than 5 seconds. As Kim gets faster, the variances in time are more subtle. Also .... Kim wanted me to time her jogging. She wasn't sure if she could jog, but she tried. 25-feet in 5 seconds. I thought it was pretty good. 25-feet of sustained jogging. Kim was disappointed that it wasn't faster than the walks. I told her that she's been doing the 25-foot walk for over a year now and the 25-foot jog for one time just now. Maybe we practice this next week again. Kim was pretty excited about jogging, despite the time.

Vanderbilt Again …. Already!

Our next trip to Vanderbilt is coming up next week. We’re going to ask questons about CCSVI, Pyruvate and Fampridine/myelin repair. Should be exciting. Ken

_________________
My Starting Point
Understanding MS 101: Doctor Talk and People Talk<br /><br />

Pulse 18

Much like last pulse, Kim’s really not having the “I’m taking Flagyl so LOOKOUT!” feeling. She does seem to be moving a little slower, but that could be a lot of things, but I’m speculating that it’s, 1) warm weather and 2) four instead of three weeks since pulse 17. We took the extra week so that Kim wouldn’t be on Flagyl when we went to her appointment in Vanderbilt.

Supplements

Kim’s still taking the Serrapeptase. We also realized that Kim’s been off her B-Complex for a few months. Normally I have a backup bottle but I must have forgotten to get one. I realized this when I looked over the list we last gave to the nurses at Vanderbilt, oops. We’re also looking into Nattokinase.

Appointment in Vanderbilt

So first off Kim tells the story better then me at Our trip to the new and most amazing “Vander-Mall”.. Below is my thoughts on the appointment.

Vanderbilt has moved the MS Center. When we got the map in the mail, it appeared that it had been moved into the middle of a shopping mall, like next to a Victoria Secret or something. But when we got there, WoW! Vanderbilt is in the process of converting a very big shopping mall into a medical center. The inside was really nice, set up like a very, very nice airport with each medical center having its own store bay. The MS center is way bigger and nicer. The only drawback was the 25-foot walk area was a brand new floor so it was “sticky and slow”. There’s a very nice bagel kiosk in the middle of it all.

Dr. Sriram was happy with Kim’s improvements. He thought the aqua aerobics was a very good thing and recommended continuing. He thought Kim should stay on the 7-day pulse and on 3 grams of pyruvate. He doesn’t have an inside scoop on Fampridine, but thinks it’s a good idea. I asked him about the Zamboni material I had sent him. He WAS NOT at all dismissive. He seems cautiously intrigued. We agreed that testing for CCSVI was something we could work into the next appointment. I think he is taking some time to more fully understand CCSVI and its possible impacts in MS. He did say that the center was bringing on a vascular neurologist very soon, isn’t that interesting?

He asked Kim if she was a coffee drinker. Apparently, the thinking is that having a cup of coffee before taking Azithromycin can/may have the same impact as taking pyruvate. I need to be clear, this sounded sort of speculative. He was simply asking about Kim’s caffeine intake, which is very, very low. He left it out there that she might want to try this, or stick with the pyruvate. He did not imply in anyway that caffeine and pyruvate should be used together. In Kim’s case, she’s happy to be on pyruvate and didn’t want to be trying caffeine. Then again, after we got home she decided she wanted to try it. I had brought Kim a latte from Starbucks and she saved it until Wednesday. She left me a voicemail shortly after taking her pyruvate with the latte, you’d have thought she was on jet fuel and Solumedrol. We don’t know how much more cryptic CPn this may have killed, but it sure gave Kim a rush.

As you can imagine, parking at the new office was a breeze. We had lunch afterward at Rafferty’s. No more Pancake Pantry, we liked Rafferty’s and will go back.

Ken

_________________
My Starting Point
Understanding MS 101: Doctor Talk and People Talk<br /><br />

Improved 25-Foot Walks on Antibiotics

Chart of Kim's 25-Foot Walk Times

Here is a most recent chart of Kim's 25-Foot Walks. The chart is clickable. So if you click on it, a new window should open that has a larger version of the chart that you can actually read.



While the chart reflects significant improvements over the first 6-months of ABX protocol, it is notable how Kim's walks are still improving as we go and that she is closing in on 4 seconds. For those of you who don't have MS, I'd invite you to measure out a 25-Foot course and see how much moving is actually involved in a 4.5 second walk.

Where, When and WOW!

We videorecord nearly all the walks in our kitchen, unless we were traveling. We have measured out the 25-Foot course with a tape that's on the floor between two floor mats. Below are the dates and times of the walks.

Links to video are blue.

Walk Date ______ Seconds

12/20/07 ________ 20.24 (1st appt. at Vanderbilt. Received Scripts for ABX)
02/17/08 ________ 10.53
02/25/08 _________ 9.63
03/03/08 ________ 10.91 (1st video of Kim walking on YouTube)
03/09/08 ________ 16.75
03/16/08 _________ 9.46
03/22/08 _________ 8.59
03/30/08 _________ 8.06
04/06/08 _________ 9.34 (2nd video of Kim walking on YouTube)
04/11/08 _________ 7.81
04/20/08 ________ 10.81
04/27/08 ________ 12.28
05/04/08 _________ 8.97
05/11/08 _________ 7.81 (3rd video of Kim walking on YouTube)
05/19/08 _________ 6.60
05/31/08 _________ 6.50
06/08/08 _________ 5.78
06/15/08 _________ 6.03
06/22/08 _________ 6.16 (4th video of Kim walking on YouTube)
06/30/08 _________ 6.06
07/13/08 _________ 7.72
07/19/08 _________ 5.19
07/26/08 _________ 5.53
08/03/08 _________ 4.72
08/10/08 _________ 5.35
08/17/08 _________ 5.50 (5th video of Kim walking on YouTube)
08/24/08 _________ 4.91
08/31/08 _________ 4.84
09/07/08 _________ 4.62
09/14/08 _________ 5.06
09/28/08 _________ 4.78
10/07/08 _________ 6.03
10/12/08 _________ 4.88
10/22/08 _________ 5.13
10/26/08 _________ 5.10
11/02/08 _________ 5.16 (6th video of Kim walking on YouTube) NEW
11/09/08 _________ 5.08
11/16/08 _________ 5.25
11/23/08 _________ 5.40
12/07/08 _________ 5.03
12/22/08 _________ 5.09
12/29/08 _________ 4.97
01/04/09 _________ 4.50
01/11/09 _________ 5.00
01/19/09 _________ 5.53
02/08/09 _________ 4.91
02/22/09 _________ 4.75
02/27/09 _________ 5.00
03/29/09 _________ 5.22
04/05/09 _________ 5.03
04/25/09 _________ 4.69
05/03/09 _________ 4.66
05/18/09 _________ 4.28
05/25/09 _________ 4.72
06/07/09 _________ 4.36
06/14/09 _________ 4.41
07/13/09 _________ 4.57
07/27/09 _________ 4.31

I do not have video of the very first walk in December 2007. The idea of doing a regular video of a 25-Foot Walk was suggested to me during February 2008. I will update this post as new videos are added.

Observations

Someone is going to want to know why the first walk is 18 months ago and I'm only getting around to posting it now. We did not know what was going to happen when Kim started ABX and we certainly didn't set out with the intention of posting video on the internet. I think folks ought to have some support for the arguments they make about off-label MS therapies. In my thinking, feeling better the next day is great, but that's not sustained improvement. We have a ways to go, but I think that 18 months of data is a good indicator.

Combined Antibiotic Protocol is working for Kim. It doesn't work for everyone. If it did, everyone would be doing it. But, it's inexpensive, needle-free and has helped some reverse the progression of their disability.

Yes, 25-Foot Walks Matter. What's Fampridine?

It is a big deal to increase your 25-Foot Walk speed. There is a company, Acorda that is in Phase III trails with an oral drug called Fampridine. When this pill is approved it's widely expected that a lot of folks with MS will be taking it. Here's a pretty good article about how Fampridine improves walking ability for some with Multiple Sclerosis.

Acorda's Fampridine trial has two significant outcomes:

35% of Fampridine recipients had improved walk speed.
8% of placebo recipients had improved walk speed.

25.2% average increase in speed in the Fampridine responsive group.
4.7% average increase in speed in the placebo responsive group.

These results are based on a 14 week trial period. I think it is great that 35% of the participants could walk about 25.2% faster. I also think it's interesting that someone in the placebo group was able to walk almost 9% faster. I think that's important, because if ABX was doing nothing, and Kim was trying really, really hard, we'd expect that she might be able to walk about 9% faster after 14 weeks.

After 14 weeks on Combined Antibiotic Protocol Kim's 25-Foot Walk time went from 20.24 seconds to 8.06 seconds. That's a 150% improvement in speed (1.24 ft/sec to 3.10 ft/sec). The kicker is that she's still improving. I'm not saying this to disparage Fampridine. Kim may very well end up taking Fampridine, but I am trying to show that the Combined Antibiotic Protocol has had an impact on Kim's walking that more than rivals the effect of an important MS drug that is being trialled entirely on it's impact on the 25-Foot Walk.

It's Not Just About Walking

We all know that it's not just about walking faster, but it's a component of the issue. We've kept track of other improvements Kim has experienced too and I'd be happy to discuss them if you are interested in knowing more about the Combined Antibiotic Protocol. Ken

_________________
My Starting Point
Understanding MS 101: Doctor Talk and People Talk<br /><br />

Better delete this until tomorrow because it doesn't make sense after your 37 edits!

Sarah

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An Itinerary in Light and Shadow Completed Dr Charles Stratton / Dr David Wheldon abx regime for aggressive secondary progressive MS in June 2007, after four years. Still improving with no relapses since starting. Can't run but can paint all day.

Pulse 19 & 20

I didn’t do a post last month because I got started on our walk video project. These last two pulses have been hard. Lots of die-off and my best correlation is that Kim’s been drinking caffeine with her pyruvate since we got back from Vanderbilt. She’s also taken an aqua-aerobics holiday because the rec. center is crazy with summer campers. This all just goes to show that after a score of pulses, there’s still a lot of CPn in there to kill. Just for accuracy, Kim’s been downing one Venti Starbuck’s Skinny Cinnamon Dolce Latte over the MWF period when she takes her pyruvate. So it’s 1 venti per week. When the pulse got hard, I asked Kim to stop drinking the latte, start taking ibuprofen and we reduced her D3.

CPn Linked to Ear Infections

Kim doesn’t generally get ear infections. A few years before Kim started ABX, she had a serious ear pain that had her crying on the bathroom floor in the middle of the night. I ran out to the 24-hour pharmacy to get anything and everything that might help. I remembered this recently when I saw a note on a message board about a person with MS who was wondering about their recurring ear infections. A little bit of checking found that CPn has been associated with ear infections.

Q: Could recurring ear infections be associated with persistent Chlamydia pneumoniae infection?
A: Yes. Studies have shown that there is a likely relationship between CPn and middle ear infection, otitis media.

Storgaard, Merete et al. 1997 Chlamydia pneumoniae in Children with Otitis Media; Molin, Gianna et al. 2005 (abstract only) A population based seroepidemiological survey of Chlamydia pneumoniae infections in schoolchildren; Ogawa, Hidesato et al. 1992 (abstract only) Recovery of Chlamydia pneumoniae, in six patients with otitis media with effusion

25-Foot Walk Videos

I have the walk video post up at a number of MS message boards now. If you do a search in Google on the words “25 foot walk” the link will come up on the first or second page of hits, isn’t that cool? If you’re searching in Google video it comes up at the top of the list, also when searching in YouTube. I was only allowed to put up one link on YouTube and I sent it to CPn Help. I was a little torn about this, but that’s where the most information is and where this approach is most accepted. Here’s a best link for getting to the “Channel” I have set up at YouTube, it’s called A Real MS Walk. What’s interesting is I get data from YouTube about the popularity of the video’s and where people click from to see them. Folks are obviously getting there from TIMS and CPn Help. But, folks are also getting there from Braintalk and Neurotalk. And ready for this, it’s popular in ….. Bulgaria!?!? I took this last week off and didn’t post a new video to see if folks would continue viewing them. The click count went down, but the searches from YouTube and Google kept going, so I think there is going to be sustained viewing. I hope so. The goal is to help others find out about, become aware of and learn about Combined Antibiotic Protocol. I’m up to 6 different MS message boards.

See walking post and its links to walk video above.

If you're reading this, you've likely seen Robbie's walking video. It is such an inspiration! Thank you Robbie. Ken

_________________
My Starting Point
Understanding MS 101: Doctor Talk and People Talk<br /><br />

More than a month behind, I finally looked up A Real MS Walk. Very neatly done!

Sarah

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An Itinerary in Light and Shadow Completed Dr Charles Stratton / Dr David Wheldon abx regime for aggressive secondary progressive MS in June 2007, after four years. Still improving with no relapses since starting. Can't run but can paint all day.

Pulses 21, 22 and 23

These were hard pulses for Kim. I didn’t keep track of the details of each but I could tell they were hard. Kim’s thoughts were something like; “Mary Poppins Never did Flagyl!!!”. This caused me to wonder about humidity again since autumn is very damp here in Northern Virginia. During December’s pulse, 23, Kim was dealing with Flagyl side effects. She was foggier than in other pulses. She was also more sluggish and sensitive to her surroundings. For example, Kim had a little tolerance for arguments between the boys. I thought that switching to Tinidazole would help. Others have posted about it being somewhat milder in side effects. Kim switched mid-pulse. She had a huge die-off event after her first Tinidazole. We were in the middle of an L.L. Bean Outlet store and Kim was ready to collapse. I wasn’t worried, but her mom was with us. We sat Kim down, and let her rest a bit. Later, she really didn’t remember what happened or what we bought. The pharmacy didn’t have enough Tinidazole and I had to wait until Monday afternoon to pick up the rest of the Tinidazole. Kim took a dose of Flagyl Monday morning and got totally wiped out again. She does not like switching between Flagyl and Tini, but I also have to wonder if she got a better die-off impact from having used both.

Why are you taking that?

Does this happen to you? You see an article or you read a post and the following day you find yourself in the vitamin shop or online ordering more supplements and you think about that article and you order a new supplement. Maybe it’s not so spontaneous, maybe you read a lot of posts and then backtrack into articles and then you buy the supplements. Fast forward. Then one day someone asks you why you’re taking Lipoic Acid and you really don’t remember and you don’t have the articles, but you vaguely recall having a ton of supporting evidence. Here’s another topic I believe to be worth documenting.

ALPHA LIPOIC ACID (ALA or LA) – ALA has been shown to inhibit NF-kB, MMP-9 and ICAM-1. ALA is also an antioxidant and has been associated with improved memory performance and mitigation of the effects of free radicals produced by porphyrins. Yadav, Vimlesh et al. 2005 Lipoic Acid in Multiple Sclerosis: A Pilot Study

Two Years

Kim’s coming up on her two year anniversary on antibiotics. We’re going to Vanderbilt in January and will have lots to talk about. We’re interested in discussing LDN with Kim’s doctor. We understand that LDN is helpful for folks who want to maintain the improvements they have fought so hard to gain. I would be interested to hear from anyone who has used ABX and LDN together, please……..

So maybe Mary Poppins has done Flagyl. Ken

_________________
My Starting Point
Understanding MS 101: Doctor Talk and People Talk<br /><br />

5th Appointment at Vanderbilt

We were both sick/getting sick with colds as we got ready for the 11 hour drive to Nashville. It was a hard trip for me, but as I see it Kim has to tough out MS everyday and the least I can do is have some resolve and determination about getting us to Vanderbilt. Kim really does inspire me, she has a remarkable spirit. Kim’s blog about her appointment is much more COLORFUL than mine – RETURN TO VANDER-MALL

MRI: Nothing new, Hooray!

Scripts: Kim likes being on Tinidazole much better than Flagyl. We brought up a past conversation about extended pulsing and Dr. S ok’ed the idea. He left it a little open-ended, so Kim is going to go at least 7 days in her next pulse and then consider adding a day. She can go up to 10. We talked with Dr. S about LDN. He seemed neutral about the idea and told Kim she could try it if she wanted. Kim got a script for 4.5.

Caffeine: Dr. S asked about Kim’s caffeine consumption again. We told him about how we were not sure about it in combination with Azithromycin because it wiped Kim out for the rest of the day. She’d get a pyruvate/caffeine high and then she’d crash. Dr. S recommended that Kim try only using coffee while she is on her Tinidazole pulse. To clarify, Kim can drink all the coffee she wants while she’s on her Tinidazole pulse. To further clarify, the method of action is related to caffeine’s ability to make the body more acidic. I asked if other things that made the body acidic would be acceptable and he said they’re really only considering coffee righ now. I got the impression that it would be good to find out what other foods make the body more acidic. Because of the “crash” effect Kim had the last time she tried caffeine with pyruvate, Kim’s been instructed to ease into her next pulse. Since her February pulse starts with an Azith/Monday, she will only take pyruvate on the first day and then she can drink coffee on the second day and she’ll use the “see how I feel” method for the rest of the pulse.

CCSVI: When we started asking about LDN, he was surprised we were not asking about CCSVI. Apparently Vanderbilt Neurology is interested in CCSVI. We really didn’t talk much about it, but the topic was left open for future discussion.

Nuclear Factor {kappa} B – NF-kB: I asked Dr. S about this, I’ve been reading a lot about it recently. I mentioned the laundry list of supplements Kim is taking and how many of them are NF-kB inhibitors:

Alpha-Lipoic Acid: (mentioned above)
Curcumin: Shishodia, Shishir et al. 2005 Curcumin: getting back to the roots
Ginkgo Biloba: Chen, Jaw-Wen et al. 2003 Ginkgo biloba Extract Inhibits Tumor Necrosis Factor-{alpha}–Induced Reactive Oxygen Species Generation, Transcription Factor Activation, and Cell Adhesion Molecule Expression in Human Aortic Endothelial Cells
N-acetyl-L-cysteine: Khachigian, Levon et al. 1997 N-acetyl cysteine blocks mesangial VCAM-1 and NF-kappa B expression in vivo
Ascorbic Acid: Carcamo, Juan et al. 2004 Vitamin C is a kinase inhibitor: dehydroascorbic acid inhibits IkappaBalpha kinase beta
1,25-dihydroxyvitamin D: Cohen-Lahav, Merav et al. 2006 Vitamin D decreases NF-kB activity by increasing IkB{alpha}levels

He found this interesting. He left me with the impresssion that the whole business of what these transcription factors do is unknown. I told him Kim was taking 4 grams of curcumin a day, which surprised him. He didn’t have any immediate opinion about NF-kB or 5-LOX inhibition, but I think he’d be interested if I sent him some papers about it. I’m going to ask Kim if she wants to reduce her curcumin but change the brand to one that is better absorbed. Perhaps increase ALA too. This discussion lead me to ask about apoptosis and the desireability of apoptosis of infected cells via (theoretical idea) NF-kB inhibition. Dr. S thinks this is fine, he does not think the oligodendrocytes are infected with CPn. Rather, he thinks it is surrounding tissue that is impacted by CPn infection. He did however add that the protocol’s approach to killing cryptic CPn should return previously infected cells to normal.

Pulse 24 ….. that means 2-Years!!!

Kim marked her two year anniversary by completing her first entirely Tinidazole pulse in the first week of January. She didn’t have the mood swings we have come to associate with Flagyl and Kim also liked that the tablets didn’t leave a disgusting taste in her mouth. Kim felt like she was experiencing residual inflammation off and on through the rest of the month. She ultimately took some Naproxen which seemed to help.

25-Foot Walk Videos

Click “HERE” to see the most up to date video post and related links to YouTube. Kim’s walk speed has stabilized for now. Sometimes she walks a little faster and sometimes a little slower. The walk videos got clicked a lot when Fampridine got approved. I can’t wait to hear from the first ABX’er to try it.

_________________
My Starting Point
Understanding MS 101: Doctor Talk and People Talk<br /><br />

Kim

what did he say about LDN? My wife's Neuro is now prescribing it for her.

Peter

Hi peter, Dr S. had NO excitement about LDN at all. i'm going for it anyway. started on 4.5 mg right off the bat. man do you dream some crazy stuff. thirsty too,maybe because you are breathing so hard while dreaming......anyways, it has been a couple weeks and I'm back to normal as far as sleeping. keep laughing at yourself, Kim

Pulse 25 – May I have Coffee with my Tinidazole?

Kim says, “It must be killing a lot of bacteria”. Dr. S suggested that Kim might want to drink coffee whenever she wants during her pulse. The goal is to make the environment in her body more acidic therefore expose more bacteria for killing. Despite being on the milder Tinidazole, Kim is experiencing die-off like she did a year or so ago. This might sound like a bad thing, but if you’re following the process, it’s a good thing. Dead bacteria is good. Some how this switch from Flagyl to Tinicoffee is making the bacteria more vulnerable. This of course increases inflammation and therefore, Kim feels the pulse again in a big way. It’s sorta like a high school senior, becoming a freshman all over again.

Day 3 was a snow day and the boys stayed home from school so I stayed home to. Kim got foggy in the middle of the day for a while and took a nap later in the day. The rest of the day was fine and Kim was moving and thinking and having a great time. It was also an Azithromycin day, which might explain a bit too – yes, Kim took her Pyruvate 30 minutes before the Azithromycin. I think it will take a while, but Kim’s going to likely find that there is a pattern to coffee consumption and how she feels.

Kim extended the pulse all the way to 10 days! It was quite an accomplishment. Then to cap it off …….

Kim Started Low Dose Naltrexone

Kim’s pumped about this. She’s getting all the side effects the LDN messageboards promise. Wild dreaming, sleep issues, difficulty walking. This is such a learning experience. I read back through this thread and I think of how much I have learned about ABX over time and I realize that I’m an LDN info newbie. So far, Kim’s started taking the LDN a little earlier, around 9pm instead of midnight. She wants to keep the dose at 4.5mg, but we’ve moved her B-Complex supplement from her day vitamins to her night vitamins. These things seem to be helping.

Bromelain

Originally the goal was to document the supplements Kim is taking and then I ran into this. I’ll suggest this one to Kim. Here are my notes about it.

Bromelain has been associated with relief of swelling, pain and inflammation. Some of these benefits have been attributed to the reduction of leukocyte adhesion. Others have noted the reductions in lipopolysaccaride induced inflammation. Bromelain may decrease IFN-y production and it may inactivate ICAM-1. Bromelain may increase the absorption of antibiotics, increasing their levels in the body.

If you’re on the Combined Antibiotic Protocol for MS here’s something else that’s intriguing:

CPn up regulates Bcl-2 and Bromelain down regulates Bcl-2
CPn up regulates NF-kB and Bromelain down regulates NF-kB
CPn up regulates COX-2 and Bromelain down regulates COX-2
CPn down regulates Bax and Bromelain up regulates Bax
CPn down regulates Caspase 3 and Bromelain up regulates Caspase 3
CPn down regulates Caspase 9 and Bromelain up regulates Caspase 9

For me, this suggests that Bromelain might help promote apoptosis of Chlamydia Pneumoniae infected cells. This is an idea well worth reading about. You might want to start with the last four references below.

Masson, Mar et al. 1995 Bromelain in blunt injuries of the locomotor system. A study of observed applications in general practice

Akhtar, Naseer et al. 2004 Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee – a double-blind prospective randomized study

Wittenborg, Alfred et al. 2000 Comparative epidemiological study in patients with rheumatic diseases illustrated in a example of a treatment with non-steroidal anti- inflammatory drugs versus an oral enzyme combination preparation

Fitzhugh, David et al. 2008 Bromelain Treatment Decreases Neutrophil Migration to Sites of Inflammation

Hou, Rolis et al. 2006 Cross-linked bromelain inhibits lipopolysaccharide-induced cytokine production involving cellular signaling suppression in rats

Jing-Rong, Huang et al. 2008 Bromelain inhibits lipopolysaccharide-induced cytokine production in human THP-1 monocytes via the removal of CD14

Mynott, Tracey et al. 1999 Bromelain, from Pineapple Stems, Proteolytically Blocks Activation of Extracellular Regulated Kinase-2 in T Cells

Shahid, Swarngit et al. 2002 Efficacy and safety of phlogenzym--a protease formulation, in sepsis in children

Hale, Laura et al. 2002 Bromelain Treatment Alters Leukocyte Expression of Cell Surface Molecules Involved in Cellular Adhesion and Activation

U.S. National Library of Medicine and the National Institutes of Health Medline Plus Bromelain (Ananas comosus, Ananas sativus)

Taylor, Rebecca et al. 2008 Box 1 | The BCL-2 family (Bcl-2 family chart’s only)

Bhui, Kamaldeep et al. 2009 Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway (abstract only)

Fischer, Silke et al. 2004 Chlamydia Inhibit Host Cell Apoptosis by Degradation of Proapoptotic BH3-only Proteins

Faherty, Christina et al. 2008 Staying alive: bacterial inhibition of apoptosis during infection

I still need to see what Kim thinks, but isn’t Bromelain interesting? Ken

_________________
My Starting Point
Understanding MS 101: Doctor Talk and People Talk<br /><br />