Just a word of caution with Minocycline. My brother's girlfriend, who took Minocycline for acne, began to experience Lupus-/Arthritis-like symptoms and linked it to the drug. She quit the drug and most of her symptoms resolved in a few weeks--a few others took about six weeks, but eventually, all resolved. Apparently, this is a possible problem, according to literature her doctor followed up on.
Here's more info:
From 1972 through February 1996, the FDA's medWatch Reporting Program had received only 1 report of a case resembling the autoimmune hepatitis described in the article by Gough et al. However, in the same time period, 32 reports were received of a systemic lupus erythematosus-like syndrome similar to the cases described by Gough et al. All patients were described either as having antinuclear antibody-positive arthralgia/arthritis, or simply as having lupus, lupuslike symptoms, or systemic lupus erythematosus. The patients were young and were receiving no other medications known to cause lupuslike symptoms; none reportedly had any relevant medical history (Table). Five reports specifically stated that the patient had been healthy until the onset of the event. Lupuslike symptoms persisted as long as 18 months prior to discontinuation of minocycline. Symptoms abated in 17 of 18 cases after discontinuation of minocycline and the time to disappearance of symptoms ranged from 2 days to 6 weeks in the 8 patients for whom that information was provided. Seven patients were rechallenged with minocycline and all experienced a recurrence of lupuslike symptoms.
Although minocycline continues to provide a relatively safe therapy in the treatment of acne, health professionals should consider its potential role in patients exhibiting lupuslike symptoms while receiving minocycline. Based on these findings, the word "transient" will be removed from the phrase "[a] transient lupus-like syndrome" in the adverse reactions section of the US product labeling.