High dose biotin interferes with B12 testing

Biotin is an emerging therapy for the treatment of secondary progressive MS.

High dose biotin interferes with B12 testing

Postby NHE » Thu Sep 24, 2015 10:23 pm

LabCorp.com states that high dose biotin will interfere with the commonly used B12 assay which utilizes biotin/streptavidin binding to quantify the B12. They refer to "high dose" as being over 5 mg/day of biotin and recommend an 8 hour wash-out period before the blood draw for the B12 test. With the 300 mg dose that's now being used by MS patients, a longer wash-out period will likely be of benefit prior to B12 testing. Note that other lab tests also use biotin/streptavidin so check with your doctor first if you're having lab work done.

LabCorp.com wrote:In patients receiving therapy with high biotin doses (ie, >5 mg/day), no sample should be taken until at least eight hours after the last biotin administration.
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Re: High dose biotin interferes with B12 testing

Postby NHE » Fri Oct 30, 2015 7:04 am

According to LabCorp, high dose biotin will also interfere with both the serum and red blood cell (RBC) folate test. They recommend waiting at least 8 hours after the last dose of biotin prior to folate testing for biotin doses >5 mg/day. Again, doses of 300 mg/day of biotin may require a longer wash-out period.
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