ElliotB wrote:biotin is biotin.
Not the case. One is a "chiral" of the other. There are actually 8 different forms of Biotin. In chemistry/drugs, the bioloigical action of different chiral forms can be and is possibly different or even negative to the desired effect.ElliotB wrote:Biotin, in its purest form, pharmaceutical grade (I have updated my original post to include this which I omitted) should in theory be pretty much the same from one manufacturer to another. I guess some expensive, time consuming clinical trial will need to be performed to determine if one is better than the other...
An enantiopure drug is a pharmaceutical that is available in one specific enantiomeric form. Most biological molecules (proteins, sugars, etc.) are present in only one of many chiral forms, so different enantiomers of a chiral drug molecule bind differently (or not at all) to target receptors. One enantiomer of a drug may have a desired beneficial effect while the other may cause serious and undesired side effects, or sometimes even beneficial but entirely different effects. Advances in industrial chemical processes have made it economical for pharmaceutical manufacturers to take drugs that were originally marketed as a racemic mixture and market the individual enantiomers, either by specifically manufacturing the desired enantiomer or by resolving a racemic mixture. On a case-by-case basis, the U.S. Food and Drug Administration (FDA) has allowed single enantiomers of certain drugs to be marketed under a different name than the racemic mixture. Also case-by-case, the United States Patent Office has granted patents for single enantiomers of certain drugs. The regulatory review for marketing approval (safety and efficacy) and for patenting (proprietary rights) is independent, and differs country by country.
ElliotB wrote:"There are actually 8 different forms of Biotin."
I did a bit of research on the various forms of Biotin and found this:
"There are eight different forms of biotin, but only one of them – D-biotin – occurs naturally and has full vitamin activity. Biotin can only be synthesized by bacteria, molds, yeasts, algae, and by certain plant species."
from this site:
http://www.nutri-facts.org/eng/vitamins ... -a-glance/
According to the PURE BULK site, their Biotin is D-biotin (from their FAQ section):
Q: "Hello I was looking for bulk d-biotin. I'm not sure if this biotin would work for me, or if d-biotin and biotin are interchangeable. I believe d-biotin is synthetic. Is this biotin synthetic?"
A: Biotin and D-biotin are interchangeable names. If you see Biotin as a name it will be D-Biotin. It is always synthetically produced as a supplement. Ours is D-Biotin.
The Bulk Supplements site does not list the type of biotin they are offering. I have emailed them and will post their response once received.
I personally would not trust a statement on the chemical itself from the people who sell it (ie financial gain/motive), and do not even manufacturer it themselves, but simply package it. The statement "Biotin and D-biotin are interchangeable name" really brings to question if the writer even knew there were 8 different types of Biotin. Additionally, I have tried looking at the stuff published on the results, and I can not find any reference to the type of Biotin used, people here have assumed its d-Biotin, yet it could possibly be any of the 7 other types. We also wont really know the true effects of Biotin until after the actual larger blinded trials are run and published. Personally I am getting suspicious of the paper. It was written by someone with a financial benefit and the results are presented more as individual case studies; the type of reports seen in a lot of questionable "studies". I also find it suspicious that the actual source of the Biotin and chemical details were not included in the paper. A lot of previous studies I have read are very specific about any chemical used and where it was source from.zen2010 wrote:I don't know....
Elliot, you sound right.
However, there is still something that bothers me about that Pure Bulk powder.
Which source? and what effects? As I personally can't say I have noticed any changes either.zen2010 wrote:I can't explain why so many people (including me) had better effects with an other pharmaceutical biotin.
Which source? and what effects?
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