First thing - happy New Year.
A belated Christmas present for Lyon and others.
Here is a link to Dr Alasdair Coles which give an overview of his work with Campath for MS. If you go down the page there is a section called Key publications. The first publication is the research article on the 3 year Phase II trial (CAMMS 223) - open the PDF file. Worth printing out as it is quite long with lots of tables / data. It may help those considering this as a possible treatment option - it sets out the benefits and some of the risks that have been seen (on the Campath and Rebif arms of the trial).
http://www.neuroscience.cam.ac.uk/direc ... php?Alcool
There are also links to other research articles on Campath - the earlier work before the formal trials. I was not on CAMMS 223 but a smaller project - 15 or so patients. I don't think Robin was part of CAMMS 223 but another project / trial. Like Robin, I think this treatment has proved extremely effective at stopping relapses / the progression of the disease for those with RR MS. The treatment is most effective earlier in the disease course - Dr Coles & co acknowledge that this present problems - the treatment comes with some risks yet those who will see the best results are those early in the disease course (with little if any permanent disability). I like Robin, have seen good recovery from some of the deficits left by my relapses and have had no relapses since my first infusion some 2.1 years ago.
Hope this is useful.
Ian
Campath research articles
- CureOrBust
- Family Elder
- Posts: 3374
- Joined: Wed Jul 27, 2005 2:00 pm
- Location: Sydney, Australia
Re: Campath research articles
OK, so I am a little late on catching this point the first time. Or it just confused me more on the second read.
One thing that has stuck in my mind is that Robin had been "upgraded" to secondary(?) progressive in 2004.bromley wrote:I don't think Robin was part of CAMMS 223 but another project / trial. Like Robin, I think this treatment has proved extremely effective at stopping relapses / the progression of the disease for those with RR MS.
http://www.thisisms.com/ftopicp-3152.html#3152Robin wrote:Diagnosed for 5 years with RRMS, recently upgraded(sic) to progressive.
I was/am part of CAMMS224. I don't know how the numbering relates to the research.
As for my 'upgrade' that was down to one form that I was presented with after being given a course fo IV steroids. In the reason for dispensation section someone had written MS - Progressive. I never did get the chance to discuss this with a neurologist.
I still have no idea how one determines whether a person is classified RRMS or one of the progressive variants. If the diagnosis for MS is a differential one in the first place how one is categorised correctly escapes me.
Despite being so categorised (even if perhaps by mistake) I decided that I had nothing to lose by giving Campath a try, although I will admit that I played down the extent of my disabilities a little in the initial interview for fear that I would not be accepted.
I don't know at what point Campath becomes ineffective. I do know that it has transformed my life and my outlook on life. That's enough for me.
Robin
As for my 'upgrade' that was down to one form that I was presented with after being given a course fo IV steroids. In the reason for dispensation section someone had written MS - Progressive. I never did get the chance to discuss this with a neurologist.
I still have no idea how one determines whether a person is classified RRMS or one of the progressive variants. If the diagnosis for MS is a differential one in the first place how one is categorised correctly escapes me.
Despite being so categorised (even if perhaps by mistake) I decided that I had nothing to lose by giving Campath a try, although I will admit that I played down the extent of my disabilities a little in the initial interview for fear that I would not be accepted.
I don't know at what point Campath becomes ineffective. I do know that it has transformed my life and my outlook on life. That's enough for me.
Robin
Do not go gentle into that good night. Rage, rage against the dying of the light.
Re: Campath research articles
.
Last edited by Lyon on Sun Nov 27, 2011 10:19 am, edited 1 time in total.
-
- Similar Topics
- Replies
- Views
- Last post
-
- 0 Replies
- 1051 Views
-
Last post by David1949
-
- 0 Replies
- 1681 Views
-
Last post by tzootsi
-
- 0 Replies
- 1456 Views
-
Last post by maggieMSOC
-
- 1 Replies
- 9641 Views
-
Last post by ElliotB
-
- 0 Replies
- 1284 Views
-
Last post by NeusFunollet
-
- 0 Replies
- 734 Views
-
Last post by NeusFunollet