This Is MS Multiple Sclerosis Community: Knowledge & Support

My sister had a kidney transplant (in 1996). She had a creatinine ratio of +/- 900 just before the transplation operation (so quite close to dialysis).

After she recovered from the operation she reported:
- Warm feet and hands (were always cold)
- Brighter colors in her vision
- Sharper vision (for digital quality to HD quality, so to say)
- No more brain fog
- Clearer mind (the thoughts were flashing through her brains again)

Her creatinine level lowered directly after the operation to 600 - 250 within one day.

The common factor she had and we have is polluted blood. She had polluted blood throughout her whole body, so also at her CNS. We do have (at least if you have CCSVI) polluted blood running partly in our system, as matter of fact: in some parts of our CNS.

Her root cause was malfunctioning (or beter: practically no more functioning kidneys). Our root cause is pinched bloodvessels at our CNS.

Both causes result in polluted blood in the CNS.

Because it is still not understood why all these phenomenons in nearly all cases are occuring directly after the CCSVI-treatment, it is somewhat interesting if there are any cross relationships between the two treatments.

I wondered: is it probably interesting to measure the creatinine ratio after the narrowing(s) in the blood vessel(s)? It can be another 'evidence' that the (non) polluted blood is a factor that is responsible for all these phenomenons as described above.

William57,
I read something Dr Simka said that might be of interest? - he
said many patients almost instantly tell him after liberation they
have warm hands and feet for the first time in a long time. He
told the Hamilton attendees this and added he thought it was
because of an angiotensin effect not nerve related. Maybe
I misread his statement it's been awhile. txs.

Hi Mangio, thanks for your reply. I recall such statement as well. Angiotensin finds its root cause in de kidneys. Angiotensin produces angiotensin II that will result in a higher liquid consumption and has also a narrowing (sic!!) effect on blood vessels (all according to Wikipedia).

It makes for me the puzzle more complicated. But there are overlapping effects. If there are overlapping causes I do not know. It only has drawn my attention.

Not sure if this is related, but I googled multiple sclerosis and angiotensin. Interesting.

http://www.sciencedaily.com/releases/20 ... 184437.htm

Inexpensive Hypertension Drug Could Be Multiple Sclerosis Treatment, Study Suggests

(A fascinating article featuring Dr. Steinman from Stanford -- a must=read in light of what we have been learning about CCSVI, especially posture and intracranial hypertension: "In response to, say, a change in posture, angiotensin immediately causes blood vessels to constrict.")

http://msj.sagepub.com/cgi/content/abstract/14/4/557

Reduction of angiotensin II in the cerebrospinal fluid of patients with multiple sclerosis

We previously demonstrated that angiotensin II acts as a crucial neuroprotective factor after neural injury through angiotensin II type-2 (AT2) receptor signaling. Although the pathway is known to play an important role in the development of experimental autoimmune encephalomyelitis, cerebrospinal fluid (CSF) angiotensin II levels in patients with multiple sclerosis (MS) have never been studied. To clarify the significance of angiotensin II in MS, we assayed angiotensin II concentrations using an established enzyme-linked immunoabsorbent assay in CSF samples from patients with MS (n = 21), patients with inflammatory neuropathies (IN) (n = 23) and control individuals who did not have either of the neurological diseases or any other disease that might affect the angiotensin II levels in the CSF (control) (n = 24). Angiotensin II levels in the CSF were 3.79 ± 1.54 pg/ml in the MS group, 5.13 ± 2.27 pg/ml in the IN group and 6.71 ± 2.65 pg/ml in the control group. The angiotensin II levels in the CSF of the MS group were significantly lower than in the control group (p = 0.00057). Angiotensin II concentration in the CSF tended to have a negative correlation with the Kurtzke’s Expanded Disability Status Scale scores during MS relapse (p = 0.0847). These findings suggest that reduced levels of intrathecal angiotensin II may be related to the abnormal neural damage and repair processes in MS.

heh bluesky,
That's a great paper. Another group from Europe published
something very similar just recently.

Four years ago a Nephrologist from Montreal told me to go
on Atacand (4mg/day) to not only save my kidneys alot of damage
from inflammation but also to try to hold back ms relapses. Many of his
mser's report no attacks for two or three years at a time - his words.

Stroke and heart doctors of course use these drugs extensively
but because of great results even eye doctors use the drug
to try to stop damage and blindness in diabetic clients. Just
ideas.

This is very interesting as blood-realesased neurotransmitters could explain the more immediate effects felt by patients 2 hours to 1 day post-op (warmer hands, improved bladder control reported by Simka in Hamilton presentation and also feeling more alert, improved sense of sensation reported by some patients in Italy)! Such immediate effects difficult to explain on basis of myelin-repair. And the placebo effect is often mentioned as possible cause.

Hope more research will be done on this potential blood-released neurotransmitter issue!

Polluted blood! Doesn't that tie in with the results I get from phlebotomy?
I got onto this blood drawing because I always got relief during my periods from the fatigue and day time sleeping (monthly MS ).
I got my first blood test in Jan 10 since getting my brain lesion in 2008 and wham, all the fatigue disappeared for four days. I felt amazing. The doctors thought I was nuts even suggesting it helped, so I donated blood the following week a full pint, and I got relief for four weeks! I mean total relief.

I had another big blood test this month and the same amazing results.
Three times in a row can't be denied, this is real!
I built a huge rock garden after the last draw, because I knew I'd be able to. I'm sleeping the odd day now, but nothing like I was prior to the blood draws. I have high iron levels due to a hemochromatosis gene, so I can take the blood draws no problem. My haemoglobin and hemocrit are higher now, than when I started this course.

My blood is being purified maybe? I just know this has to fit in somehow, somewhere, which is why I am here getting the word out. I'm feeling so good, even if I have relapsed slightly.

The doctor is still skeptical but can't really deny the results.