MarkW-there is a ton of references to various journals that have linked to hemochromatosis gene to MS on the thread Phlebotomy Anyone. I do not want to repeat them here. This genetic mutation is also related to other iron loading diseases like Alzheimer's, Parkinson's, Huntington's. I ask and I ask I ask the same question... how does iron get into the brain of all of these other conditions? Iron in the brain is not unique to MS, something most people did not realize. It is the transferrin protein that deposits iron into the brain, this has been known for a very long time. Don't you think it is significant that this occurs in all of these other conditions that are related to the genetic mutation for hemochromatosis? Or am I covering old ground and you already know all this?
Iron overload and upregulation of iron-handling proteins, such as TfR, in the MS brain can contribute to pathogenesis of Multiple Sclerosis and iron imbalance is associated with a prooxidative stress and a proinflammatory environment, this suggest that iron could be a target for MS therapy to improve neuronal iron metabolism.
This is but one of hundreds of studies. Given your background, I would ask that you remain open-minded about our findings, and help us determine how many people with MS are sick due to iron overload as a metabolism issue. And at this point, we do not know how far phlebotomy can take us. According to the Iron Overload Disease organization of Florida, they have seen remarkable recoveries in some neurodegenerative conditions using phlebotomy when iron panels indicated iron overload. In a way none of this is new, there are people out there that have known for decades that iron overload due to genetics affects a broad population and they can be cured. Until Zamboni however, I did not know about the iron connection. I am questioning a different modality of treatment, that will be accessible to all. The reason you do not see links between MS and hemochromatosis is because they have not recognized properly that the heterozygote population overloads iron to a lesser degree. There is also a ton of studies showing this. Again, there is absolutely no harm in doing a simple blood test. You can't argue against it in any logical fashion. It is just a blood test and we are uncovering to a startling degree just how many people there are that fit a hemochromatosis profile, me included. I am primary progressive MS, Zamboni would not help in any case, so please lend your support in our investigations because we are on to something that is just as important as CCSVI. People should be jumping up and down for joy that we can identify the MS population that are iron loaders, and the possibility that the treatment will cure.
I am sitting in a wheelchair, I have been doing that for six years, and I am amazed at the improvements I have received from two phlebotomies, Bethr from just one. Since I am probably the first person in the world to do thi with primary progressive MS, I agree we need more investigation/clinical trials. But can you please tell me of any other therapy for primary progressive MS that actually reverses symptoms??? My improvements have held and I believe I have a chance of complete recovery. The other argument for this whole thing, besides the fact that PP MS cannot be treated by Zamboni's methods is that it is totally affordable in any country of the world. Bloodletting is as ancient as history, has a very good track record for hemochromatosis.