newlywed4ever wrote:MORE Importantly! I agree with you about a study using fake venoplasty by not inflating; I cringed when I read that post.
Donnchadh wrote:First of all, as someone who actually underwent the balloon procedure, it would be very difficult to partially inflate a balloon just enough for a MSer to perceive it and at the same time not be enough to relieve the stenosis.
girlgeek33 wrote:What is the highest percentage of any "placebo" effect?
drsclafani wrote:i think designing trials is going to have to take this into consideration. How can we remotely follow up without losing patients to followup
Cece wrote:girlgeek33 wrote:What is the highest percentage of any "placebo" effect?
35% is the number to beat...also apparently the more effort you go to for a treatment, the higher the placebo effect (and travelling in order to get surgery is a fairly high effort)....
girlgeek33 wrote:If safety studies and studies to measure lesions and measure degree of symptoms are all done, can't the significance of the results be enough.
Cece wrote:girlgeek33 wrote:If safety studies and studies to measure lesions and measure degree of symptoms are all done, can't the significance of the results be enough.
I think this is exactly what Dr.S concluded, many pages back: if the pilot studies come back with overwhelming results, then no need for the randomized trials.
That collateral is significant because it indicates that there is an outflow obstruction. I do not think it is that large by the way. In another ten years it might be large.....but by then you would possibly be EDSS 5. I think one reason the collateral flow is so impressive is because the catheter tip is directly into the orifice of the collateral. It will push the contrast through the path of least resistsance.
unfortunately the views of the outflow at the confluens are just not the best.
Nor is the imaging of the Azygous vein (spelled correctly, i might add!) partaicularly good. Image quality is weak and the view is not a profile view of the arch of the azygous.
I am very impressed with the "waist" on the balloon of the upper jugular. I wasnt expecting that!
let us know how your next doppler looks
JOJOB wrote:Hello Dr Sclafani,
I have myself a question to ask you.
I had a doppler in Paris with DR...., He did not find anything specially wrong with my jugulars except for the valve not working properly in my left jug. He told me to sleep in the inclined position. He also told me to come back to him in the next few months to have my azygous veins checked as he thought that a problem could be there.
In the meantime I have contacted an interventionist radiologist who believes in CCSVI and he programmed an MRV without any dye for the week after next. Is there any particular thing I should ask when they do it ? I have an appointment later with the dr, but it seems unlikely to me that the problem will be detected if it is lower down the azygous veins. If my understanding is correct, the only real method of finding anything is to have a catheter venogram. I would really appreciate if you could give me any guidance.
Thank you in advance.
For info: MS diagnosed 2005, 15 lesions on the brain plus one particularly annoying lesion at the top of the spinal cord that has been the subject of the last 4 relapses.
girlgeek33 wrote:Reading all the postings about randomized trials and sham surgeries it occurred to me, can't we just do studies without needing to have such things? What is the highest percentage of any "placebo" effect? From the number of people I have communicated with that have had the liberation procedure, almost everyone has significant improvements. If safety studies and studies to measure lesions and measure degree of symptoms are all done, can't the significance of the results be enough. There are so many of us, we would be lining up for these studies, well we already are, most seem to get on every list possible. I guess what I'm asking is that if significant results show in these types of studies, isn't that enough for the scientific community? Especially if we are talking about quality of life. That's what all of us with MS really care about!
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