mshusband wrote:I'm looking for an answer Dr. Sclafani had about finding different types of stenosis or causes of stenosis in the veins ... (I think the answer mentioned leaflets, valves, twisting, flaps) ...
drsclafani wrote:The body and its pathology is rarely that boring. In the case of CCSVI, there are so many variations of the disease and its anatomical pathology
To date I have seen the following: In most patients they are mixed
1. Anomalous confluens of jugular vein
2. Absent Jugular vein
3. annular stenoses
4. hypoplasia, isolated
5. hypoplasia, multiple tandem
6. duplications with stenosis
7. reversed valve
8. incomplete or fused valve leaflets
9. misplaced valve
10. false channels (may be incomplete jugular duplication)
13. abnormal drainage of external and vertebral veins
So variation is the rule.
I'm just trying to think outside the box. Any thoughts or comments would be welcome.
1eye wrote:I'm just trying to think outside the box. Any thoughts or comments would be welcome.
Quite right, Larmo. Not to be morbid but maybe more post-mortem stuff is appllicable. The police use great tools, and for this they might use an ALS. Because human eyes don't see some other wavelengths too.
bestadmom wrote:Dr. S is in Italy with Paolo Zamboni for the week with no internet access. We probably won't hear from him until next weekend.
Stacemeh wrote:I don't know about iron types but here is something I wonder about:
Hemolysis can occur when normal red cells are exposed to turbulent blood flow in large vessels, an example of which includes tramatic disruption (sounds like reflux to me) of red cells in heart disease.
Hemolysis = rupture of erythrocytes (red blood cells) with release of hemoglobin into the plasma (the fluid portion of blood).
What I wonder is if refluxed blood (due to venous stenosis) is sometimes releasing a bit of hemoglobin and that free hemoglobin is "sticking" to the vessel walls and over years (perhaps in a vicarious luxuriant fashion ) this hemoglobin is accumulating and breaking down leaving iron behind.
From past experience in Vet practice I happen to know that heme staining leave a kinda redish tint, not unlike that in pictures I've seen of MS lesions.
So, I wonder if this might explain the discoloration seen on the plaques formed in MS and if it might also explain why red cells have not been found by pathologists in MS lesions.
But I am not a doctor, I can only speculate.
mshusband wrote:Cece (or anyone else) ... since I can't find what I'm looking for and you seem to be more adept at doing so using whatever you're using ... perhaps you can find this for me.
I'm looking for an answer Dr. Sclafani had about finding different types of stenosis or causes of stenosis in the veins ... (I think the answer mentioned leaflets, valves, twisting, flaps) ... but I can't remember how long ago it was (nor do I have time to read 115 pages - THANK YOU SO MUCH DR. SCLAFANI FOR ALL OF THIS, SERIOUSLY, YOU'RE A GODSEND FOR INFORMATION - otherwise we'd all be adrift still).
If you can find that for me ... I think the answer also mentioned the best way of imaging those types of malformations ...
I'd really appreciate it.
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