drsclafani wrote:Trish317 wrote:drsclafani wrote:girlgeek33 wrote:Cece wrote:I am also once again holding my breath for IRB news. I do this a lot, around here.
Ditto, Dr. S. any update on what is happening with your IRB process for approval? Will they get back to you soon or wait another month, until next meeting to make a decision?
they had some reservations but did not make a decision. they want to speak to a neurologist and to a neuroradiologist, neither of whom are likely to know as much about ccsvi as I do.
the IRB brought up two publications that concerned them. One was the german article stating that there is no good correlation between ccsvi and ms. i have to be able to rebut this paper so i looked for it. but it is in a german journal. I went to the journal webpage and bought the article.
Mind you, i have only two years of high school german, and i only got a B. But the article seems less than convincing. Does everyone know that the authors imaged only 10 patients with MS and 7 patients with no evieence of ms.
they did not find a correlation but it was not statistically significant in proving their point. it was offensive to paolo Z and robert Z.
the other paper was pure opinion. not fact.
if they want to harrass me, then let them but we shall see on monday when another emergency meeting of the IRB is being scheduled.
BTW, if you are tortured by this, join the club
Hi Dr. S,
Cheerleader has been evaluating the German paper on this thread in the General Forum....
And this one in the CCSVI forum....
http://www.thisisms.com/ftopic-12225-45 ... rasc-.html
As usual, her research and evaluation are spot on.
this was helpful to me.
the reason dr zamboni wants the study done in inspiration is to activate the thoracic pump and increase blood flow through the jugular veins. it is the overwhelming of the outflow volume that leads to the reflux in ccsvi.
and how did she get the paper in english?
i paid $34. to get a copy in german
Awwww, I don't know..... ....but she posted right after I did that she'll send it to you.
cheerleader wrote:Dr. Sclafani--I have the German paper translated, as it was published in the Annals of Neurology. PM me with your e-mail and it's yours, or you can get it yourself-
No cerebro-cervical venous congestion in patients with multiple sclerosis
Florian Doepp, MD1; Friedemann Paul, MD1,2; José M. Valdueza, MD3; Klaus
Schmierer, PhD4,5*; and Stephan J Schreiber, MD1*
http://www3.interscience.wiley.com/jour ... 6/abstract
I've been going thru it with a fine toothed comb. I can find a few discrepancies with the Zamboni protocol regarding loci of the transducer and valsalva/IJVVI as opposed to true venous reflux, and their method of measuring blood volume was quite convoluted....but I know you'll find many more. Good luck...I'm sure Dr. Zamboni will be making a full reply to this paper.