Thanks Dr. the valves make more sense to me now, I was approaching the problem by looking at how to 'fix' it rather than cure the cause of the problem. So the valves are there to stop reverse flow from the heart beating lower down the vein (the on off effect from blood being taken into the heart?), rather than the reverse flow from a restriction in a vein?
Is it possible that the reflux/back flow has a hydraulicking effect because of the pulsing of blood flow?
I am trying to get my head around the way lesions come and go and how they are spread around the brain?
My thought was that waste and de-oxygenated blood could be circulated around the brain because of reflux in no or low pressure, gravity draining areas around the brain, because of this pumping effect.
In situations where there is muscle pinching of veins the amount of restriction would change with muscle use would it not?
Some muscles would be in 'use' and block veins because of its position/posture and that would change its severity of restriction on the vein as the muscle flexes?
Does the BBB breach originating in the clevical spinal cord and then the CSF pumping the breached content around the brain make sense to you?
Again I am trying to find answers to why the RRMS form happens, when the 'truest' form of the disease PPMS is about progression in a less episodic fashion. In the RRMS BBB first breaches then inflammation responds, this seems to happening like the glutamate cascade effect in Strokes, and the disease still has the underlying continuous nature of PPMS. So finding the cause of the RRMS breach would be of value in understanding what is happening to trigger the immune system.
Is it possible that lesions in the vein walls (passages) could 'grow' through to the CSF space and cause the BBB breach?