NZer1 wrote:Hi everyone, Dr S I have been doing a catch up on the thread and I have noticed a commonality that has crossed from Dr. F's thread as well.
The bottom line is in regard to age and the veins themselves. Is it possible that the finding of the Hubbard group where a familiaral trend for vein issues such as the findings in the Hubbard family is part of the picture here.
If time and all the other factors that de-generate a vein create a worse 'stenosis' effect, one that exists already but not causing symptoms as they have each got, the valve finding may possibly the last cab on the rank when MS symptoms occur like with Devlin.
By improving the vein flows the outcomes have been so wide in result, that said the best standard and the findings from repeating angio treatment finding incomplete treatments are throwing the data as said earlier as well.
I am at risk of waffling here, sorry.
The bottom line of my drift is that the malformation findings are only relevant because of aging effecting the blood flow.
The article Nunzio translated hints at this, as well as some of the less improved outcomes since treatment. Basically the entire vascular system is challenged by age and inherent issues become life effecting with age and poor health practices and diet may have had the greatest detriment and advanced the disease known to us as MS.
In addition if you throw in a trauma to restrict the blood return for sufficient time you will have the same outcome.
Whip lashes and the other accident related injuries that compress or misalign the vascular system have now been shown to predate an MS type onset.
The other clue to my thinking is Marc's compressed my muscle example, although he would have aged with this situation the impact on flow may have also been age and condition of the vein, which lead to collapse, which may have in relative time been resent.
Basically it seems to me that the valves are a bandage fix that may not be sustained.
The flow testing into and out of the brain repeated over time may be a clue for children at risk, such as Cece's. There could be huge learning from a longitudinal test to see what happens for children showing symptoms that are dismissed by current medical people because of the lack of awareness of blood flow restrictions, reflux and the outcome, fatigue to name one symptom.
“We are confident that the Pantera Lux is a solid alternative for in-stent restenosis and possibly for other indications that physicians struggle with where the placement of a permanent device is not optimal.”
Results from several pre-clinical and clinical studies indicate that short-term exposure of injured arteries to paclitaxel delivered from regular angioplasty balloons may be sufficient to reduce late lumen loss and restenosis rates during a critical period of time after the angioplasty of diseased coronary and peripheral arteries. Although the number of published trials and patients treated is still limited, data available seem to prove that restenosis inhibition by immediate drug release is feasible.
Algis wrote:Doctor: again a wild thought over here:
If blood clotting is leaving markers in the blood; would it be thinkable of a device as people use to monitor sugar-levels in their blood? i.e.: a little quick puncture on the tip of a finger and a result on a small probe inserted?
That could screen candidates?
ThisIsMA wrote:Hi Dr. Sclafani,
I recently read a reference to using in-vein radiation (I'm sure I'm not using the proper medical term) to prevent coronary artery restenosis. In the process of reading more about that on the web, I came across an article on using drug-coated balloons to prevent restenosis.
Then I found one such balloon that is already on the market. Here is a press release from the balloon manufacturer about the introduction of this balloon:
http://www.biotronik.com/portal/19898/? ... &pid=25913“We are confident that the Pantera Lux is a solid alternative for in-stent restenosis and possibly for other indications that physicians struggle with where the placement of a permanent device is not optimal.”
And here is a link to an advertisement for this balloon (don't worry, I have no ties to the medical device-making sector!):
Would this balloon or one similar (if there are others out there) be useful in preventing restenosis in CCSVI treatment?
Here is a quote from a more general article on the concept of drug coated balloons to prevent restenosis:
http://www.touchneurology.com/articles/ ... ortunitiesResults from several pre-clinical and clinical studies indicate that short-term exposure of injured arteries to paclitaxel delivered from regular angioplasty balloons may be sufficient to reduce late lumen loss and restenosis rates during a critical period of time after the angioplasty of diseased coronary and peripheral arteries. Although the number of published trials and patients treated is still limited, data available seem to prove that restenosis inhibition by immediate drug release is feasible.
I know arteries are quite different from veins. But I am hoping that intimal hyperplasia in a vein and in an artery might have the same cause, and therefore could be prevented by the same treatment? The drug used in the balloon is an anti-cancer drug that limits cell overgrowth.
I would definitely pay more for the use of a drug-coated balloon in a first CCSVI treatment, if there were a reasonable chance it could prevent restenosis. I'm one of those people whose health insurance won't cover CCSVI, and who can't afford to pay for more than one treatment.
Thank you so much for all the amazing work you do!
newlywed4ever wrote:Since I have a LIJV that is occluded due to 1) scar tissue, 2) blood clot or 3) first angio was not actually in the IJV, I am wondering... does it make any sense to balloon maybe one of the larger collaterals if the IJV can't be treated?
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