New Haacke document: iron in different neurological diseases

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New Haacke document: iron in different neurological diseases

Postby thisisalex » Thu Mar 25, 2010 2:50 pm

It looks like there is a project description on dr. Haacke's site, which describes his international project which tries to investigate the role of iron in different kinds of neurological diseases. not just MS. Which is a brand new perspective on the topic of venous diseases...

Title is: "Probing the etiology of neurological diseases using iron as a biomarker of vascular damage"

He set 3 hypothesis in his document, which has to be proven:
Damage to the vascular system may play a major role in a number of key neurological diseases than has heretofore been thought. ... This proposal will highlight the need to rethink the role of both arterial and venous disease in aging and cancer for the former and MS, stroke and traumatic brain injury (TBI) for the latter. Therefore, my main focus is on the role of vascular damage in neurological diseases and the overarching hypothesis of this proposal is:

Hypothesis One: “A major cause of diverse neurological diseases is vascular damage, the effects of which can be seen with magnetic resonance imaging (MRI).”

Hypothesis Two: “Iron can serve as a surrogate marker for tissue damage, it can be seen in the form of ferritin and hemosiderin using SWI and will directly show the presence of vascular damage.”

Hypothesis Three: “Monitoring the early involvement of the microvascular system will make it possible to discover the etiology/pathogenesis of these diseases, to diagnose them more effectively at an earlier stage and hence to treat them more successfully.”



here you can download it:
http://www.ms-mri.com/grants.php

alex
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Postby Merlyn » Thu Mar 25, 2010 3:54 pm

Methinks that it is the iron itself that does the damage, and the iron has accumulated due to faulty iron metabolism... why not just run a few iron metabolism panels?
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Postby mshusband » Thu Mar 25, 2010 3:56 pm

I'm sorry Merlyn ... what is your obsession with saying Iron EVERYTHING ... in EVERY thread?

You act like these Iron Panels you flout are the be all end all ...
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Postby Merlyn » Fri Mar 26, 2010 12:23 pm

MS husband-well, maybe my obsession makes a lot more sense than trying to measure the iron accumulation after-the-fact. Who cares if you could measure iron accumulation in the brain by location or by weight??? Stop it from happening in the first place, the concept is called preventative phlebotomy, and it is not unknown. Until people realize that this is already understood in science, I will keep harping. We need to know how many people develop MS due to iron overload. We need to know how to prevent it from happening in the first place... and believe it or not, some people e-mail me with appreciation of the fact that I am asking these questions. Have you run an iron metabolism test? People that do this are amazed at the results, and are then grateful that someone like me started asking this question in the first place, does iron accumulation in the brain have anything to do with iron metabolism... more and more it is obvious that the answer is yes.

http://ms-mri.com/history.php

It has been long thought that iron misregulation is associated with neurodegenerative disease. There is an extensive recent review of iron in neurodegenerative diseases by Kell (30). Although this will require much more detailed experimentation (30) there is certainly some evidence for it in specific disease such as neuroferritinopathy, aceruloplasminemia and hemochromatosis, for example. In the latter case, Thomas and Jankovic (31) stated: "The presence of central nervous system superficial siderosis and central nervous system vasculitis, in association with systemic hemosiderosis, may be the neurological manifestation of hemochromatosis." (In hemochromatosis, iron levels are sometimes reduced with either chelation or with phlebotomy.) They go on to note that iron elevation follows dopaminergic cell death. On a different but related note, there is some suggestion that the amount of stored iron might also play a role in risks of white matter damage post injury (31). Sullivan suggests that there is evidence that oxidative DNA damage as measured by 80HdG correlates with the amount of stored iron. A very interesting paper by Patt et al (33) and another by Grant et al (34) both suggest that reduced iron levels are associated with reduced damage to the brain. The former reports that: "Gerbils fed a low iron diet for 8 weeks had decreased brain and serum iron levels, less neuroloigical deficits and decreased brain edema after temporary unilateral carotid ligation (ischemia) and then reperfusion than gerbls fed a control standard of iron diet." The latter reports that experimental automimmune encephalomyelitis (EAE) did not develop in low iron mice. They also suggest that: "The mechanism of EAE inhibition in iron deficient mice likely involves the delivery and metabolism of iron for optimal CD4+ T-cell development." In their paper they also comment that iron supplementation has been shown to increase progression and mortality in HIV-infected people and that iron chelation in mice with EAE also reduced the clinical severity of the symptoms.
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Postby cheerleader » Fri Mar 26, 2010 1:32 pm

Alex-
Thanks for posting this information. Dr. Haacke is really at the forefront of studying the vasculature in relation to brain health.

Merlyn-
Dr. Haacke is not looking at iron metabolism in his tests, he is studying the microvasculature and how vascular damage contributes to neurological disease. I am sure that iron metabolism can make damage worse, but you need to understand that this is NOT what Dr. Haacke is testing. He is studying the delivery of blood in the brain. Iron is essential to brain health, to creating myelin, to neurological health. When the vessels leak, due to venous congestion or microvascular damage, blood, heme, plasmic particles, etc. are deposited into brain tissue. That is what Dr. Haacke is studying.

Don't know how to say this any more clearly. Jeff's iron panels were fine...no issues with iron metabolism for him. He had two occluded jugular veins. We're glad you are helping people...but understand that iron overload is not a problem for everyone here-
thanks,
cheer
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dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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