Relationship of Iron to Oligodendrocytes and Myelinization

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Postby Billmeik » Thu Apr 22, 2010 7:51 am

Ive been thinking about it and the two mechanisms you define should be compared and contrasted to see if one can disappear. It would be nice if a single mechanism emerged.
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Postby Billmeik » Thu Apr 22, 2010 8:16 am

its interesting that http://www.sciencedaily.com/releases/2003/10/031022062049.htm

buffalo was on the iron theory in 2003
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Postby 1eye » Mon May 30, 2011 11:17 am

I expect if there is reflux there is hypoxia. The flow of blood is a complex area of study; experts in rheology may have some opinions on the probabilities, causes, and consequences of reflux in these vessels. Wikipedia states:
Blood is a suspension of cellular elements in plasma, therefore exhibit non-Newtonian flow behavior. That is, its viscosity is shear rate dependent. Blood viscosity decrease with increased shear rate, known as shear thinning.

Blood viscosity is determined by plasma viscosity, hematocrit (volume fraction of red blood cell, which constitute 99.9% of the cellular elements) and mechanical behavior of red blood cells. Therefore, red blood cell mechanics is the major determinant of flow properties of blood. Red blood cells have unique mechanical behavior, which can be discussed under the terms “erythrocyte deformability ” and “erythrocyte aggregation ”.[2]

Blood viscosity can be measured by viscometers capable of measurements at various shear rates, such as a rotational viscometer.[3]

Of course oxygenation will affect the properties of red blood cells as well, and the effect may become circular.
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