This Is MS Multiple Sclerosis Community: Knowledge & Support

Welcome to the world's leading forum on Multiple Sclerosis research, support, and knowledge. For over 10 years, This is MS has provided an unbiased community dedicated to Multiple Sclerosis patients, caregivers, and affected loved ones.
It is currently Sat May 25, 2013 5:27 am

View unanswered posts | View active topics


Board index » Treatments » Chronic Cerebrospinal Venous Insufficiency (CCSVI)

All times are UTC - 8 hours [ DST ]



Post new topic Reply to topic  Page 1 of 1
  [ 7 posts ] 
  Print view Previous topic | Next topic 
Author Message
questor
PostPosted: Mon Jun 07, 2010 2:39 pm 
Offline
Family Elder
User avatar

Joined: Mon May 22, 2006 3:00 pm
Posts: 216
Location: Northern Calif Monterey Bay Area
An MS_social_worker/friend pointed me to this site for general MS information from a neurologist's perspective:

Masters of MS Website

Dr. Zivadinov is featured this month with focus on CCSVI. Nothing surprising in what he says, but I liked his careful and concise statement to the neurological/MS_patient community :

"My view at this point is that CCSVI is associated with MS; however it is yet to be determined whether CCSVI is among the risk factors that, along with others, increase a person’s susceptibility to developing this disease. The fact that CCSVI prevalence is about 38% in patients with a first clinical attack of MS and almost 90% in those with secondary progressive MS and a disease history of 20 years suggests to me that venous insufficiency has a high likelihood of affecting people with MS over time."

--Tracy

_________________
CCSVI Procedure 9/16/2009 at Stanford
Stent in left and right IJVs
SPMS
Copaxone and Ampyra user
Top
 Profile  
 
eric593
 Post subject:
PostPosted: Mon Jun 07, 2010 2:59 pm 
Offline
Family Elder
User avatar

Joined: Sun Feb 17, 2008 4:00 pm
Posts: 449
Thanks.

How have you been doing since your procedure?
Top
 Profile  
 
questor
 Post subject:
PostPosted: Mon Jun 07, 2010 4:14 pm 
Offline
Family Elder
User avatar

Joined: Mon May 22, 2006 3:00 pm
Posts: 216
Location: Northern Calif Monterey Bay Area
From the About page at the Masters of MS site:

More information has been published about multiple sclerosis (MS) in the past decade than in the entire history of medical literature. Clinical practices even a few years out of date may not be in the best interest of our MS patients. But it’s nearly impossible to keep up with all the advances, much less apply them in a disease that varies greatly among patients.

That’s why we created MastersofMS.com. This website is a forum for specialists with the latest expertise on MS to share their knowledge with you, the MS clinician. It’s simple: register for the site, enter your question, and our experts will address it directly. Or browse the archived topics on the site.

Given that the expected audience of this site is the MS clinican, I think Dr. Zivadinov's comments are especially meaningful.

eric593, I've been updating a topic at this site with my progress (it varies day to day):

http://www.thisisms.com/ftopicp-112319.html#112319

--Tracy

_________________
CCSVI Procedure 9/16/2009 at Stanford
Stent in left and right IJVs
SPMS
Copaxone and Ampyra user
Top
 Profile  
 
Shayk
PostPosted: Mon Jun 07, 2010 7:34 pm 
Offline
Family Elder
User avatar

Joined: Fri Feb 06, 2004 4:00 pm
Posts: 750
Tracy

Thanks for posting this. I find Buffalo's results of CCSVI in people with SPMS pretty interesting.
Quote:
CCSVI prevalence ..........almost 90% in those with secondary progressive MS and a disease history of 20 years

I've come across some info on another condition, "Leukoaraiosis", "a major cause of vascular and dementia in the elderly" where it's been suggested that jugular venous reflux may be relevant.

Pathogenesis of leukoaraiosis: role of jugular venous reflux
Quote:
Chronic cerebral hypoperfusion associated with vasogenic edema, microbleeding or/and endothelial dysfunction found in LA favors venous ischemia, in stead of arterial ischemia, as its pathogenesis.

The involved regions in LA, periventricular and subcortical regions, are the drainage territory of deep cerebral venous system and the watershed region between the superficial and deep cerebral venous system respectively....

cerebral venous hypertension caused by downstream venous outflow impairment might play a major role in the pathogenesis of LA.

Internal jugular vein is the main venous outflow pathway for cerebral venous drainage.

The frequency of jugular venous reflux (JVR) is increased with aging.

Hypertension, which has a decreased venous distensibility, might further exacerbate the sustained or long-term repetitive retrograde-transmitted cerebral venous pressure and venous outflow insufficiency caused by JVR.

Clinically, JVR caused by a dural AV fistula does lead to cerebral hypoperfusion, white matter abnormalities, vasogenic edema and cognitive impairment in several published reports.

JVR is suggested to play a key role in the pathogenesis of LA through a sustained or long-term repetitive retrograde-transmitted cerebral venous pressure and venous outflow insufficiency, which might lead to chronic cerebral venous hypertensions, abnormal cerebral venules structural changes, decreased cerebral blood flow, endothelial dysfunction, and vasogenic edema in cerebral white matters.

Clearly, the highlight as it pertains to the Buffalo findings re: 90% CCSVI in people with SPMS, is that it would appear that jugular venous reflux gets worse with age, so the Buffalo results could be consistent with jugular venous reflux, at least viewed through this lens. There's also research indicating that disability levels in MS are related to age.

And, just to make it really interesting, here's Wikipedia's take on leukoaraiosis
Quote:
Leukoaraiosis is a term for changes in the cerebral white matter that can be detected with high frequency by CT and MRI in aged individuals.

It is a descriptive term for rarefaction of the white matter.

It is also commonly referred to as white matter hyperintensities (WMH) due to its bright white appearance on T2 MRI scans.

Underlying vascular mechanisms are suspected.

This white matter pathology is inconsistently associated with cognitive impairment, motor dysfunction, and gait disturbances. Slowed cognitive speed of processing and frontal executive abilities are also common.

Sounds kind of familiar to me.

Unrelated, but I just now saw this abstract and it may have already been posted, but interesting nonethless since there's lots of optic neuritis associated with MS.

Jugular venous reflux affects ocular venous system in transient monocular blindness

Take care all and thanks again Tracy. Hope more improvements consistently come your way.

Sharon
Top
 Profile  
 
Cece
 Post subject:
PostPosted: Mon Jun 07, 2010 7:41 pm 
Offline
Family Elder

Joined: Mon Jan 04, 2010 4:00 pm
Posts: 8511
Wow, Sharon, interesting find.

_________________
"However, the truth in science ultimately emerges, although sometimes it takes a very long time," Arthur Silverstein, Autoimmunity: A History of the Early Struggle for Recognition
Top
 Profile  
 
cheerleader
 Post subject:
PostPosted: Mon Jun 07, 2010 8:21 pm 
Offline
Family Elder
User avatar

Joined: Mon Sep 10, 2007 3:00 pm
Posts: 4682
Location: southern California
Sharon---fabulous find. This is from Dr. Chung, who has been studying venous reflux/jugular valve insufficiency in TGA and other neurovascular situations. No wonder CCSVI gets worse with disease progression...aging doesn't help.

The Zivadinov interview is OK. He mentions two deaths (???) which continues to irritate me...but he's still researching the link, and that's the important thing.

Tracy--it was good to see your name pop up. Think of you often, and hope there are more better days than worse ones...and that there is still more healing ahead,
cheer

_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS


Top
 Profile  
 
Guider
 Post subject:
PostPosted: Mon Jun 07, 2010 8:40 pm 
Offline
Family Member
User avatar

Joined: Fri Jun 04, 2010 3:00 pm
Posts: 51
Location: Newfoundland, Canada
Why is it that we can't see the forest for the trees :?: :?: Amazing info.

Thanks for posting.




Guider

_________________
Live to the fullest; Love passionately; Laugh contagiously!
Top
 Profile  
 
Display posts from previous:  Sort by  
Post new topic Reply to topic  Page 1 of 1
  [ 7 posts ] 

Board index » Treatments » Chronic Cerebrospinal Venous Insufficiency (CCSVI)

All times are UTC - 8 hours [ DST ]

Related topics
 Topics   Author   Replies   Views   Last post 
There are no new unread posts for this topic. Our very own Anna featured on CTV

CureIous

3

1016

Fri Jul 23, 2010 9:37 am

annad View the latest post

There are no new unread posts for this topic. Vascular Access Center featured on CNN

Cece

0

483

Mon Dec 05, 2011 7:34 pm

Cece View the latest post

There are no new unread posts for this topic. Inclined Bed Therapy Featured in New Pathways Magazine MSRC

[ Go to pageGo to page: 1, 2 ]

AndrewKFletcher

28

5288

Mon Feb 21, 2011 11:25 am

AndrewKFletcher View the latest post

There are no new unread posts for this topic. Dr Zivadinov and BNAC !!!!

[ Go to pageGo to page: 1, 2 ]

ozarkcanoer

22

3945

Tue Jan 26, 2010 6:46 am

bestadmom View the latest post

There are no new unread posts for this topic. Zivadinov confused?

[ Go to pageGo to page: 1, 2, 3 ]

costumenastional

33

4214

Sat Feb 13, 2010 5:43 am

Chris1967 View the latest post

 


Who is online

Users browsing this forum: Rosegirl

You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum

Search for:
Jump to: