Harvard Professor Bakshi on iron in the MS brain and CCSVI

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Harvard Professor Bakshi on iron in the MS brain and CCSVI

Postby cheerleader » Tue Sep 28, 2010 7:44 am

The current expert on iron in the MS brain (along with Dr. Mark Haacke), Dr. Rohit Bakshi, recently spoke at the University of Ferrara.

From the Italian press---Professor Rohit Bakshi of Harvard University came to Ferrara University to discuss how his decade long study of iron deposition in MS brains has now intertwined with Dr. Zamboni's research:

Google translate of the press release:
Too much iron, more severe disease
New Ferrara - September 24, 2010 page 19 Section: Commentary
"It 's another piece of the puzzle that is made," says the researcher Paolo Zamboni.To place a new tile on the mosaic of research on multiple sclerosis was yesterday Professor Rohit Bakshi, Harvard University, came to Ferrara to explain the outcome of a decade of study during which he analyzed the role of iron as a contributory cause of the disease. His line of research was independent from that beaten by Ferrara Zamboni, but its conclusions have been come to intertwine with the results of tests carried out by the researcher and neurologist Bologna Ferrara Fabrizio Salvi on Ccsvi, which have established a hypothetical link between stenosis of the venous vessels in the brain iron accumulation and the onset of multiple sclerosis.

"The current therapies - said the scientist in the main hall of the university - are not effective in stopping the neurodegeneration. Bakshi was able, with a common magnetic resonance imaging to measure the actual concentration of iron in the brain, an operation in the past only run during the autopsy. Plaques and iron stores were associated, but especially "the greater the presence of iron - Bakshi said - the more you exacerbate the effects of the disease." Studies have revealed that the abnormal presence of iron affects the white matter and gray and tends to cause atrophy of certain areas of the brain.


EDIT to link to correct original press:
link

link to other press

Here is an article on Dr. Bakshi's studies of MS and iron deposition from 2003:

link to Iron in MS Brain
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Last edited by cheerleader on Tue Sep 28, 2010 12:24 pm, edited 2 times in total.
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Postby sbr487 » Tue Sep 28, 2010 9:45 am

Just weeks back I had posted a paper authored by Dr. Bakshi.
Someone posted host of papers by this Dr and surprisingly lot of papers were co-authored with Dr. Zivadinov ...

Interesting times ahead though I wish there was more collaboration between neuro and vascular scientists, as Dr. S says ...
A new scientific truth does not triumph by convincing its opponents and making them see the light, but rather because its opponents eventually die and a new generation grows up that is familiar with it
- Max Planck
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Postby cheerleader » Tue Sep 28, 2010 10:49 am

You're right, sbr--Dr. Zivadinov and Dr. Bakshi collaborated on a few studies on iron deposition at Jacobs in Buffalo. This has been ongoing for the last decade or so, since the advent of SWI MRI technology. It is also why Dr. Zivadinov became interested in studying CCSVI. Dr. Mark Haacke also became interested in Dr. Zamboni's research, after years of noting iron deposition in MS brains and neurodegeneration in gray matter.

Here are a couple of the papers these neurologists and researchers had written prior to Zamboni's research:

Haacke's full paper--Characterizing iron deposition in multiple sclerosis lesions using susceptibility weighted imaging (written before he read Zamboni's research)

http://www.ncbi.nlm.nih.gov/pmc/article ... s83445.pdf

Bakshi with Jacobs Neurological--
http://msj.sagepub.com/content/12/4/437.abstract

Dr. Bakshi had been quiet regarding his views on CCSVI. He invited Dr. Zamboni to Harvard to speak in March 2009, but this is the first time he has spoken out regarding his research into iron deposition and the connection to CCSVI. These are the "iron and MS brain" neurological experts. And they are reaching across disciplines to consider the vascular implications. Hope Dr. Bakshi might consider joining the International Society of Neurovascular Diseases.
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Postby Cece » Tue Sep 28, 2010 11:39 am

(reminder to take my green tea capsules!!)
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Postby cah » Tue Sep 28, 2010 12:08 pm

intertwine. Wonderful word! Didn't know it until now. :)
"There is only one good, knowledge, and one evil, ignorance." Socrates
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Postby cheerleader » Tue Sep 28, 2010 12:27 pm

cah wrote:intertwine. Wonderful word! Didn't know it until now. :)


auf deutsch es ist verflechten, ja? :)
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Postby cah » Tue Sep 28, 2010 1:16 pm

Hey, wow! 8O :)

Even better is "ineinander greifen", like gearwheels do. "Intertwining" makes things going (faster), was my thought after putting it into the translator. :)
"There is only one good, knowledge, and one evil, ignorance." Socrates
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Postby NZer1 » Tue Sep 28, 2010 3:27 pm

Thanks as always Joan, feels like we are getting some more traction, be interesting to hear how Dr. Zamboni is getting on with his accessory vein studies!
Regards Nigel
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Postby Johnson » Tue Sep 28, 2010 3:50 pm

I'm glad to "hear more voices" on the matter. My MRV (Haacke protocol) looks like microscopic bird shot (I'll dig out the pic). I also have significant atrophy of my grey matter, which makes me really sad. My next step is to prove medical science wrong, and fill up my cranial vault with grey matter again.

Danke fur school am Deutsch. I will see if I can ineinander greifen "verflechten" into any conversation I have while passing through Frankfurt en route to Poland next week.

Or maybe I won't... I might end up saying that I have a feather, and I want to go to Cuba. Or something.
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Postby cheerleader » Tue Sep 28, 2010 7:54 pm

verflechten is close enough to verklempt for me :)
Johnson, if anyone can re-grow gray matter, my money is on you.

Just noticed this: from Dr. Bakshi's site, upcoming research to be published:
Filippi M, Roca MA, Barkhof F, Bakshi R, Fazekas F, Khan O, Pelletier D, Rovira A, Simon J (2011)
Multiple sclerosis and chronic cerebrospinal venous insufficiency: the neuroimaging perspective,
AJNR American Journal of Neuroradiology, In Press
http://www.drbakshi.com/

I'm a bit concerned to see Filippi, Barkof, and Khan's names on this paper, since they were co- authors of the first negative commentary on CCSVI in MS that was published in the Annals of Neurology last February--we'll see.
http://onlinelibrary.wiley.com/doi/10.1 ... 22001/full
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Postby Johnson » Wed Sep 29, 2010 1:01 am

verflechten is close enough to verklempt for me Smile
Johnson, if anyone can re-grow gray matter, my money is on you.

Aw cheer, I'm all verklempt now...

grazie and a grin
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Postby malden » Thu Sep 30, 2010 5:15 am

Iron in Chronic Brain Disorders: Imaging and Neurotherapeutic Implications (... Rohit Bakshi)

http://www.neurotherapeutics.org/article/S1933-7213(07)00090-6/abstract
...However, the link between observed iron deposition and pathological processes underlying various diseases of the brain is not well understood.


http://www.mssociety.org.uk/applications/discussion/view.rm?post_id=994227&id=14320
From the Italian press---Professor Rohit Bakshi of Harvard University came to Ferrara University to discuss how his decade long study of iron deposition in MS brains has now intertwined with Dr. Zamboni's research:
...
its conclusions have been come to intertwine with the results of tests carried out by the researcher and neurologist Bologna Ferrara Fabrizio Salvi on Ccsvi, which have established a hypothetical link between stenosis of the venous vessels in the brain iron accumulation and the onset of multiple sclerosis.
...

hypothetical link:
link assumed by hypothesis; supposed; highly conjectural; not well supported by available evidence.
malden
 

Postby CureOrBust » Sat Oct 02, 2010 3:07 am

I thought there was some article where Dr Haake did not find evidence of iron deposits in all MS brains; autopsy I thought?
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Postby Billmeik » Sat Oct 02, 2010 10:29 am

so here we have an important bridge that's hopefully getting built. From traditional neurology to ccsvi. I have lately found the study of vericose veins to be reallly useful. There is iron deposition. There is an epedemiology that closely match ms (2/3 female, away from equator)..it is the resonant metaphor. Iron desposition is understood in the legs isnt it?
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Postby cheerleader » Sat Oct 02, 2010 12:52 pm

In Le Monde---9/30/10
translation thanks to google translate-
Here's the original--
le link

This time, it is Professor Rohit Bakshi of Harvard who, after ten years of research, confirms the importance for the scientific hypothesis of a venous origin of multiple sclerosis (deficiency cerebrospinal venous chronic or IVCC CCIVS).

On September 23, 2010, he met Dr. Zamboni at the University of Ferrara (Italy) and detailed the role of iron in multiple sclerosis. However, the two researchers have explored the subject in a completely independent vis-à-vis the other. But their findings lead to the same conclusion: there is more iron in the brain, the more there is an exacerbation of the disease. And the incorrect presence tends to cause atrophy of certain brain regions.

This reinforcement allows medical Paolo Zamboni to declare that a new piece of the puzzle has finally been released. It also fits perfectly with the results of tests performed by Fabrizio Salvi, neurologist and researcher, on a hypothetical link between vein stenosis and the appearance of multiple sclerosis because of the accumulation of iron produced in the brain.

Prof. Bakshi was able to measure the actual concentration of iron in the brain by MRI, which was done before that in autopsies.

These developments argue for an intensification of research (still stalled in France) as demanded by thousands of people affected by this tragic disease. They are also more likely to spin overseas to benefit from angioplasty they are denied at home. It is through this simple process involving the rupture of the blood-brain barrier by eliminating venous stenosis.
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