Leukoaraiosis is an ischaemic demyelination of the immediate periventricular white matter associated with astrogliosis, enlarged extracellular spaces and white matter microcavitations. It is secondary to chronic global reduction of brain perfusion. Leukoaraiosis, which appears as an area of hyperintense signal in the white matter on MR images, is an age-related neurodegenerative condition that, when severe, correlates with dementia. It is characterized histologically by demyelination, loss of glial cells, and spongiosis.
What Dr. Chung has suggested with jugular venous reflux in LA sounds a lot like what Dr. Haacke and Hubbard are discussing in CCSVI with hypoperfusion....
Here's is Dr. Chung's abstract:
Leukoaraiosis (LA) is a major cause of vascular dementia and disability in the elderly. Age and hypertension are the most two important risk factors. Despite its clinical significance, the etiology is so far unclear. Chronic cerebral hypoperfusion associated with vasogenic edema, microbleeding or/and endothelial dysfunction found in LA favors venous ischemia, in stead of arterial ischemia, as its pathogenesis. The involved regions in LA, periventricular and subcortical regions, are the drainage territory of deep cerebral venous system and the watershed region between the superficial and deep cerebral venous system respectively. Adding the facts that periventricular venule collagenosis, and retinal and intraparenchymal venules dilatation are related to the severity of LA, cerebral venous hypertension caused by downstream venous outflow impairment might play a major role in the pathogenesis of LA. Internal jugular vein is the main venous outflow pathway for cerebral venous drainage. The frequency of jugular venous reflux (JVR) is increased with aging. Hypertension, which has a decreased venous distensibility, might further exacerbate the sustained or long-term repetitive retrograde-transmitted cerebral venous pressure and venous outflow insufficiency caused by JVR. Clinically, JVR caused by a dural AV fistula does lead to cerebral hypoperfusion, white matter abnormalities, vasogenic edema and cognitive impairment in several published reports. JVR is suggested to play a key role in the pathogenesis of LA through a sustained or long-term repetitive retrograde-transmitted cerebral venous pressure and venous outflow insufficiency, which might lead to chronic cerebral venous hypertensions, abnormal cerebral venules structural changes, decreased cerebral blood flow, endothelial dysfunction, and vasogenic edema in cerebral white matters.
--and not to overstate the obvious, but it doesn't take an autoimmune disease to create white matter lesions, demyelination and cerebral atrophy. These can be caused by venous outflow abnormalities.