Kidney Int. 2000 Aug;58(2):575-86.
Zinc deficiency further increases the enhanced expression of endothelin-1
in glomeruli of the obstructed kidney.
...We therefore designed the present study to examine the effect of Zn deficiency on the expression of ET-1...
...the expression of prepro-ET-1 mRNA and ET-1 was substantially increased in the OK of the Zn-deficient diet group
relative to the OK of the standard diet group...
http://ajplung.physiology.org/cgi/conte ... 80/5/L1040
Am J Physiol Lung Cell Mol Physiol 280: L1040-L1048, 2001;
Endothelin B receptor deficiency potentiates ET-1
and hypoxic pulmonary vasoconstriction
Endothelin (ET)-1 contributes to the regulation of pulmonary vascular tone by stimulation of the ETA and ETB receptors.
Although activation of the ETA receptor causes vasoconstriction, stimulation of the ETB receptors can elicit either vasodilation or vasoconstriction
The actions of ET-1 are dependent on activation of at least two receptor subtypes, ETA and ETB.
ETA receptors are located on smooth muscle cells and mediate vasoconstriction and smooth muscle proliferation (17, 36).
In contrast, ETB receptors are present on both endothelial and smooth muscle cells
in the rat pulmonary circulation...
i am still investigating potential causes of ETB receptor deficiency.
i have been trying to find out if the ETB receptor involves a zinc finger, which would make sense if correcting zinc deficiency lowers ET-1.
but, can't verify yet. have to switch tracks for the moment. will revisit later.