Adrenal insufficiency increases serum zinc concentrations whereas administration of glucocorticoids, corticotropin, and the excess cortisol production in Cushing’s Syndrome decrease these concentrations [reviewed in (38)]. Hypercortisolemia and hypozincemia are associated with chronic alcoholism (39). Excess cortisol could accelerate pancreatic zinc release and produce a systemic zinc deficiency as observed in alcoholism. Radiotracer kinetic studies with humans reveal that carbohydrate-active steroids (glucocorticoids) may alter rate constants of the fecal excretion of zinc (38). Hypozincemia associated with glucocorticoid action has been related to induced synthesis of MT in rodents (40). GR involvement in pancreatic tissue organization and the differentiation of acinar cells, as well as enzyme and zymogen granule production is compatible with a role in ZnT2 regulation. Furthermore, the control zinc provides via MTF-1 responsive ZnT2 expression is consistent with a homeostatic role in endogenous zinc secretion. However, how the correlation of serum zinc and cortisol levels influences pancreatic ZnT2 expression requires further studies. To our knowledge ZnT2 may represent the first member of either the ZnT or Zip families to be glucocorticoid regulated.
NZer1 wrote:"Vitamin D research is discussed in light of the hypothesis that the lower average levels of vitamin D frequently observed in autoimmune disease are not a sign of deficiency.
Instead, it is proposed that the lower levels result from chronic infection with intracellular bacteria that dysregulate vitamin D metabolism by causing vitamin D receptor (VDR) dysfunction within phagocytes."
http://autoimmunityresearch.org/transcr ... eprint.pdf
I take from that Ed that testing for Vit D is much more complex in the reading of results and there often needs to be further tests to decide if it is high use or VDR dysregulation by Bacteria or viruses?
Plus the calcium balance in this equation as well!
Just when I thought I was beginning to understand I am sat on my arse once again with lack of knowledge at a new level, and that's life all over
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