jimmylegs wrote:i consider the passing mention of multimineral use only in the context of those with poor absorption to be irresponsible, especially if people take high doses, absorb it, then experience side effects without understanding possible links to mineral depletion. oversimplification, but i've hammered that gong plenty on this thread already.
Mean serum level of magnesium was 1.87 ± 0.37, copper 110.7 ± 19.5, and zinc 85.4 ± 13.5 in patients (control group), and 2.22 ± 0.24, 133.7 ± 13.4, and 110 ± 8.3 respectively in case group. This difference is statistically significant (P< 0.001).
http://paleohacks.com/questions/113534/ ... fects.htmlI became aware of the close association between vitamin D and magnesium after receiving emails from people experiencing magnesium deficiency symptoms after they began taking high doses of Vitamin D.
I've been taking 5,000IU of Vitamin D pretty much daily since I'm not getting much sun this winter. It seems I get kinda light headed, dopey, and I feel "out of it". Is that because I'm magnesium deficient? Yesterday I didn't take any Vitamin D, and I felt fairly normal. Could that be a hint to me? Any ideas or suggestions?
This is what made me wonder: http://www.naturalnews.com/029195_magne ... min_D.html
High intake of total, dietary or supplemental magnesium was independently associated with significantly reduced risks of vitamin D deficiency and insufficiency respectively. Intake of magnesium significantly interacted with intake of vitamin D in relation to risk of both vitamin D deficiency and insufficiency. Additionally, the inverse association between total magnesium intake and vitamin D insufficiency primarily appeared among populations at high risk of vitamin D insufficiency. Furthermore, the associations of serum 25(OH)D with mortality, particularly due to cardiovascular disease (CVD) and colorectal cancer, were modified by magnesium intake, and the inverse associations were primarily present among those with magnesium intake above the median.
Evidence clearly shows that magnesium and vitamin D [1 alpha, 25-dihydroxyvitamin D3; 1,25(OH)2D3] independently affect numerous aspects of the immune system. ... this paper identifies numerous places in common where both magnesium and vitamin D reportedly affect immune function. ... there are compelling reasons to believe that examining interactions between magnesium and vitamin D within the immune system could prove rewarding, especially since the physiological statuses of both nutrients in human populations are less than optimum.
Taking vitamin D for long periods of time in doses higher than 4000 units per day is POSSIBLY UNSAFE
In 34 intervention studies including 2805 individuals with mean 25(OH)D concentration lower than 50 nmol/L at baseline supplementation with 50 μg per day or more did not show better results. ... The discrepancy between observational and intervention studies suggests that low 25(OH)D is a marker of ill health.
muse wrote:A FB buddy told me that one of my public FB-notes is circulating on TIMS, so just a short reply regarding proper Mg-testing.
---Mg-Serum tests are pretty worthless. Period.---
Best Arne p.s. ...better to open a new thread to discuss the topic because it's complex.
“...Just 1% of the body’s Mg is circulating in our blood stream. The rest is hidden in our body tissue (60% in the bones 39% in soft tissue like heart, brain, liver, kidney, glands, & muscles with highest concentration in the ventricles of the heart) and the body will do EVERYTHING (until it’s to late/heart attack) to keep this level!
There can even exist a 'Mg-paradox' if you are already highly deficient in this mineral but a simple blood test will come up with a ‘to much’ in blood serum. This shows only that your clever body is desperately trying everything to prevent the worse case scenario (heart attack) by sucking up minerals from your bones/teeth/brain etc. to support the vital body functions....”
Anonymoose wrote:Have to hop in here with my big mouth. Markw...people with ms are not the general population. I suspect we feel nutrient imbalances before the general population (I feel neurological effects of iron, calcitriol, and copper imbalances at barely high or low levels). And due to the demands of our ever present inflammatory cascade, our nutrient demands are surely higher.
(Thank goodness we can count on Jimmylegs for the rational presentation of studies. )
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