mjc701 wrote:Cece, do you have a links to the actual protocol details (not the information on clinical trials.gov)?
I couldn't find them if they're out there.
If my memory is correct, I know that Dr. Dake's imminent trial has a sham arm but he kept the length of the trial to 3 months. There are no stents being tested in this initial trial, only ballooning vs placebo.
Dr. Siskin's trial is limited to patients who live locally so that they're able to keep up with the follow-up. I have assumed but have no real way of knowing that he'll use the same anticoagulation in the trial that he uses with his other patients (Plavix, IMO not the best choice, but I could be wrong about that).
I know the least about Dr. Mehta's trial. It has an ambitious large-scale (400 patients being treated, 200 in the sham arm). With his regular patients, he treats them in two separate procedures as he'll only treat a single jugular at a time due to concerns about risk, but someone said that in his trial he will do it in a single procedure.
Here's what bestadmom had to say about the small Georgetown trial that was abruptly stopped due to lack of results:
I know for a fact that Georgetown has ceased it's treatments,. The outcomes were not what they wanted - patients restenosed and they wouldn't retreat them. Also, the azygos wasn't properly imaged and to do so midstream meant changing a fixed protocol.http://www.thisisms.com/ftopicp-132012.html#132012
It was said that Dr. Neville of Georgetown was going to be publishing a paper on this, I can't imagine that'll be positive.
Also from bestadmom in that link, Dr. Lynn in FL also has something that's IRB approved. I haven't heard much about that, perhaps it's a registry or pilot study.