Dr. Thanaporn's mouse model of CCSVI!!!

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Dr. Thanaporn's mouse model of CCSVI!!!

Postby Cece » Wed Feb 16, 2011 10:47 am

9.00 > 9.15 A murine model of CCSVI is associated with
mild but significant impairment of gait as assessed by
neurobehavioral testing - P. Thanaporn USA

I googled murine, it means mouse! This is the ccsvi mouse model, with mild but significant impairment of gait.

This will be presented at ISNVD next month. Who is Dr. Thanaporn? What do you think, mild impairments in gait, as long as it's significant it is a decent model for ccsvi? I belive they simply ligated both jugulars in the mice, forcing the blood flow to find other ways out from the brain.

Do mice have anything analagous to an azygous?

Someone has said that mice have a 2-year lifespan, is that accurate for these research mice?
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Postby pairOdime » Wed Feb 16, 2011 11:11 am

Genetically Determined Variation in the Azygos Vein in the Mouse
http://www.cs.tut.fi/~sanchesr/Biddle/p ... 9_1991.pdf

The normal mouse is expected to have a single and left-sided azygos vein that develops from the paired embryonic cardinal venous system and drains most of the right and left thoracic walls into the left anterior vena cava.
It's a paradigm shift
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Postby pairOdime » Wed Feb 16, 2011 11:36 am

Dr. Porama Thanaporn
http://cvmedicine.stanford.edu/vascular ... s.html#koy

Porama Koy Thanaporn joined the Section of Vascular Medicine in the Division of Cardiovascular Medicine as clinical fellow in 2008. Koy received his undergraduate degrees in Bioengineering and Biology at the University of Pennsylvania summa cum laude where he was a Benjamin Franklin Scholar and was elected to Tau Beta Pi Engineering Honor Society.

Dr. Thanaporn connected with Dr. John Cooke’s (specialist in Vascular Medicine and endothelial biologist) research team at Stanford. Here is the link for Dr. Cooke.

http://cvmedicine.stanford.edu/vascular ... outus.html
It's a paradigm shift
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Postby cheerleader » Wed Feb 16, 2011 1:02 pm

Yup...that's my hero, Dr. Cooke and his colleague at Stanford. He read the Endothelial Health program I'd created for Jeff in the fall of 2009. It was based on his research for The Cardiovascular Cure. He wrote me back and we became e-mail correspondents. When the Zamboni paper was released in December '09, I sent it to him to read, and he said he thought there was something to it. He then gave the paper to Michael Dake, his office neighbor at Stanford. Dr. Dake read the paper and ended up meeting Dr. Zamboni at the Charing Cross Vascular Symposium the next week-- then coming home to Stanford and calling us up to test Jeff.

It's all still a bit extraordinary to me...I call it divine providence, others might call it coincidence. But I'm proud to know Stanford is continuing to study this.
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dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Postby codefellow » Wed Feb 16, 2011 1:07 pm

Clearly, the mouse and the researchers are deluding themselves with a reverse-placebo effect. The mouse knows its veins have been altered, and it wants to please the researchers, who know exactly what they are hoping to see, and so the mouse limps a little.

The only way this test will ever prove anything is if you have one standard mouse, one with EAE, and one with the synthesized CCSVI, and of course, no one, researchers or mice or those collecting the results, can know which is which.

In other words, you have to at least use THREE BLIND MICE!!

:P

(This contributes nothing to the discussion, so I fully expect the moderator to delete it soon, but if it provides a couple of smiles before that, so be it.)
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Postby MS_HOPE » Wed Feb 16, 2011 1:45 pm

codefellow, you got me smiling! I love you guys.
CCSVI:  Making Sense of MS
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Postby 1eye » Wed Feb 16, 2011 2:05 pm

codefellow wrote: :P

(This contributes nothing to the discussion, so I fully expect the moderator to delete it soon, but if it provides a couple of smiles before that, so be it.)


Saw it, smiled. :D
"Try - Just A Little Bit Harder" - Janis Joplin
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'MS' is over - if you want it
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Postby AlmostClever » Wed Feb 16, 2011 2:20 pm

Any mention of MS-like lesions or iron deposition?
If you can't explain it simply, you don't understand it well enough. - Al Einstein
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Postby garyak » Wed Feb 16, 2011 2:23 pm

8) :D
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Postby mavis » Wed Feb 16, 2011 3:47 pm

Lots of :lol: from me too. Very much appreciated on a day like I'm having.
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Postby prairiegirl » Wed Feb 16, 2011 3:52 pm

Contributions to smiles appreciated here 8) !
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Postby MrSuccess » Wed Feb 16, 2011 4:11 pm

study must be reviewed by skeptical mice .... in order to validate the results .





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Postby Cece » Wed Feb 16, 2011 4:16 pm

three blind mice - love it!!!
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Postby ozarkcanoer » Wed Feb 16, 2011 5:17 pm

Cece.... Where is Dr Thanaporn's paper that you quoted from !!!! This is the biggest news since Dr Zamboni's original paper and we would all love to read it. I know I (who have had the procedure) knew that the mouse model would be a turning point.

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Postby ppicklee » Wed Feb 16, 2011 5:28 pm

Saw it and smiled. Thanks! :-)
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