Missing Link? Endothelin1 high in pwMS

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Re: Missing Link? Endothelin1 high in pwMS

Postby Cece » Tue Jul 01, 2014 7:17 am

Billmeik wrote:Restoring CBF by interfering with the ET-1 system warrants further investigation as a potential new therapeutic target for MS.

k do.

Mice and rat research on endothelin all use an endothelin anti-serum

On the rat RDS model produced by intravenous injection of oleic acid, , it was for the first time found that endothelin (ET) level in bronchoalveolar lavage fluid was elevated by 3-fold: and that preadministration of ET-antiserum to rat with RDS significantly improved its hypoxemia, pulmonary edema and histologic injury; inhibit the leakage of protein and intracellular enzymes from alveoli. The results suggest that ET might play an important role in the pathogenesis of RDS, and that treatment against ET would be a new approach for RDS.

This could be used to lower ET-1 in humans, if it were tested.
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Re: Missing Link? Endothelin1 high in pwMS

Postby Cece » Tue Jul 01, 2014 7:25 am

Eating walnuts reduces ET-1 dramatically (in hamsters)

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Re: Missing Link? Endothelin1 high in pwMS

Postby pairOdime » Tue Jul 01, 2014 8:06 am

Men and women (n = 15, 9 women and 6 men) aged 21–60 years


J Nutr. 2013 Jun;143(6):788-94. doi: 10.3945/jn.112.170993. Epub 2013 Apr 24.
Acute consumption of walnuts and walnut components differentially affect postprandial lipemia, endothelial function, oxidative stress, and cholesterol efflux in humans with mild hypercholesterolemia.

Berryman CE1, Grieger JA, West SG, Chen CY, Blumberg JB, Rothblat GH, Sankaranarayanan S, Kris-Etherton PM.
1Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA.

In conclusion, we showed that acute consumption of walnut oil favorably affects endothelial function compared with whole walnuts and walnut skins.
It's a paradigm shift
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Re: Missing Link? Endothelin1 high in pwMS

Postby pairOdime » Tue Jul 01, 2014 8:47 am


J Hypertens. 2013 Mar;31(3):521-9; discussion 529. doi: 10.1097/HJH.0b013e32835c1d01.

Tomato extract and the carotenoids lycopene and lutein improve endothelial function and attenuate inflammatory NF-κB signaling in endothelial cells.

Armoza A1, Haim Y, Bashiri A, Wolak T, Paran E.
1Soroka University Hospital, Faculty of Health Sciences, Ben-Gurion University, Beer Sheva, Israel.

A wide number of functional and inflammatory markers were investigated in two cultured endothelial cell models [EA.hy926 and human umbilical vein endothelial cell (HUVEC)], exposed to oleoresin and carotenoids lycopene and lutein. All the carotenoids significantly improved basic endothelial function as measured by increased nitric oxide and decreased endothelin (ET-1) release. They were effective in attenuation of inflammatory nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signalling: decrease of tumour necrosis factor-alpha (TNF-α)-induced leukocytes adhesion, expression of adhesion molecules inter-cellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1), and nuclear translocation of NF-κB components as well as some revert of inhibitor of kappa B (IκB) ubiquitination. In addition, the carotenoids were able to inhibit NF-κB activation in transfected endothelial cells. When combined with lutein, oleoresin exerted synergistic effect on preclusion of leukocytes adhesion.

Prevention of over-expression of adhesion molecules through inhibition of NF-κB signalling may be one of the main mechanisms driving carotenoids to attenuate inflammatory leukocyte adhesion to endothelium. This is the first profound study on the mechanisms involved in the positive action of natural tomato products in endothelial cells.
It's a paradigm shift
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Re: Missing Link? Endothelin1 high in pwMS

Postby ThisIsMA » Tue Jul 01, 2014 3:37 pm

Thank you for posting this article about carotenoids. I am allergic to Walnuts, so its great to know that there's other alternative natural foods that might help!

Here's the wikipedia page on carotenoids, and an excerpt from it.


Carotenoids are organic pigments that are found in the chloroplasts and chromoplasts of plants and some other photosynthetic organisms, including some bacteria and some fungi. Carotenoids can be produced from fats and other basic organic metabolic building blocks by all these organisms. Carotenoids generally cannot be manufactured by species in the animal kingdom so animals obtain carotenoids in their diets, and may employ them in various ways in metabolism.
Maybe this is why the Wahls Protocol may work! Terry Wahls who is a MD who has MS suggests we eat a total of 9 cups a day of leafy greens, sulfer containing veggies, and brightly colored fruits and veggies (3 cups of each).

Another excerpt from the wikipedia page I linked to above says:
Since dietary lipids have been hypothesized to be an important factor for carotenoid bioavailability, a 2005 study investigated whether addition of avocado fruit or oil, as lipid sources, would enhance carotenoid absorption in humans. The study found that the addition of both avocado fruit and oil significantly enhanced the subjects' absorption of all carotenoids tested (α-carotene, β-carotene, lycopene, and lutein).[7]

So it sounds like its good to eat some healthy oils with your fruits and veggies, so that the carotenoids can do their thing!

I think there was a recent study showing that the reason the Mediterranean Diet is good for health is the combination of olive oil and veggies eaten at the same time. Maybe for the same reason?
DX 6-09 RRMS, now SPMS
Still work, still walk, but not very far.
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Re: Missing Link? Endothelin1 high in pwMS

Postby THX1138 » Wed Jul 02, 2014 5:54 pm

Assessment of the effects of endothelin-1 and magnesium sulphate on regional blood flows in conscious rats, by the coloured microsphere reference technique

There is evidence to suggest that magnesium (Mg2+) is beneficial in the treatment of a number of conditions, including pre-eclampsia and acute myocardial infarction. The mode of action of Mg2+ in these conditions is not clear, although the vasodilator properties of Mg2+ are well documented both in vitro and in vivo.

In conclusion this, and our previous studies, have shown that MgSO4 can reverse vasoconstriction in a number of vascular beds, and indicate that this compound may have therapeutic benefit in conditions associated with vasospasm.

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