Restenosis is a major clinical problem following successful percutaneous transluminal coronary angioplasty. Since magnesium has vasodilator and antithrombotic effects, this study was designed to evaluate its potential to decrease the rate of restenosis.
In an open-labelled, randomized controlled study, 148 patients underwent successful coronary angioplasty. Ninety-eight patients were treated with ...[IV] magnesium sulphate ... 49 of them continued with oral supplements of magnesium hydroxide 600 mg. ... 50 patients served as controls (group C).
... A trend towards a lower rate of restenosis (>50% reduction in luminal diameter) was noticed in the magnesium groups (28/110, 25%) compared with the control group (20/53, 38%) P=0.10. ...
It is concluded that intravenous administration of magnesium in patients undergoing coronary angioplasty is feasible and safe and that the beneficial trend of magnesium to prevent acute recoil and late (within 6 months) restenosis is encouraging and should promote further investigation in a larger patient population.
jimmylegs wrote:If you have an MS diagnosis, you are likely to have a constellation of nutrient imbalances that have been extensively researched.
If you are considering invasive surgery as a preventive measure, you might be interested in optimizing nutritional status first, or in conjunction with, any CCSVI investigations.
The first thing to understand when beginning nutrition investigations, is the unfortunate language of the lab. Specifically, the term 'normal'.
The 'normal' range is often quite a broad range which in many cases includes both sick and healthy people.
There is a much smaller range within the normal range that can be described as 'optimal'.
For example, the normal range for zinc is 10-20 umol/L. ms patients average in the low teens. healthy controls average in the high teens.
One example of the danger of the word 'normal' is this: recently a patient here at TIMS asked for a zinc test and was told the level was fine. When the patient asked for the number it came back 10.083 umol/L. This patient was not told that the level was suboptimal, or even borderline deficient, just that it was 'fine' - ie the computer did not red flag it because the value was within the min and max setpoints. (6/30 edit: i was reading a source today which listed the normal range for zinc as 11.5 - 18.5 umol/L so by that definition of normal, the TIMS patient was actually deficient. just a different set up at the lab and you're fine )
Another example: the normal range for uric acid is 140-360 umol/L. MS patients average 194 umol/L. Healthy controls sit in the 290-300 umol/L range. Interestingly, uric acid levels are positively correlated with zinc levels. So if you are low in zinc you are likely to be low in uric acid too. read more: http://www.sciencedirect.com/science/ar ... 1787800416
Suspect nutrients for MS patients include but are not limited to:
vitamin b complex (all of them, particularly b12)
essential polyunsaturated fatty acids
All of the above are also important for optimal vascular health.
There are specific targets for vitamin d3, magnesium, zinc and uric acid here: http://www.thisisms.com/ftopicp-15460.html#15460
Note the hemoglobin minimum of 13, too.
If your lab does not use the same units as shown, feel free to ask me about conversion.
Here is a useful conversion resource:
http://www.unc.edu/~rowlett/units/scale ... _data.html
If you have any questions feel free to comment or send me a private message.
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