I'm trying to understand one thing. MS is linked to immune system cells that are activated to remove the deposited iron deposits in the brain because of CCSVI. Once we restore a normal venous outflow, how do we "turn off" the cells of the immune system?
adaptivemind wrote:I'm trying to understand one thing. MS is linked to immune system cells that are activated to remove the deposited iron deposits in the brain because of CCSVI. Once we restore a normal venous outflow, how do we "turn off" the cells of the immune system?
You are asking the $ 1 mil. question for which, fortunately, there is an answer that is scientifically and experimentally proven beyond any possible doubt: HSCT (Hematopoietic Stem Cell Transplantation). HSCT is a procedure by which the immune system is rebooted and rendered 'immune naive'.
As to why the immune system goes banana's and reaps havoc to the nervous system is a question for which there as many answers as the number of MS researchers you may speak to. Viruses, faulty genes, stress, vit. D defficiency, a combination of all, etc.
Whatever the trigger may be, at this point CCSVI and iron deposition remain an unproven theory and speculation, yet to be confirmed or refuted in carefully designed scientific research and trial. As tempting as it may seem, as things stand, there is no basis what so ever to speak of CCSVI and iron deposition as a matter of fact.
Vikingquest wrote:"liberation treatment is vastly superior to HSCT in producing a beneficial result to MS patients"
I assume that this is a joke?
Step away from the CCSVI Cool-Aid, and do not drink it anymore. Normal cognitive function will resume after it leaves your system.
Have you even read the figures for HSCT?
Between January, 2003, and February, 2005, 21 patients were treated. Engraftment of white blood cells and platelets was on median day 9 (range day 8–11) and patients were discharged from hospital on mean day 11 (range day 8–13). One patient had diarrhoea due to Clostridium difficile and two patients had dermatomal zoster. Two of the 17 patients receiving alemtuzumab developed late immune thrombocytopenic purpura that remitted with standard therapy. 17 of 21 patients (81%) improved by at least 1 point on the Kurtzke expanded disability status scale (EDSS), and five patients (24%) relapsed but achieved remission after further immunosuppression. After a mean of 37 months (range 24–48 months), all patients were free from progression (no deterioration in EDSS score), and 16 were free of relapses. Significant improvements were noted in neurological disability, as determined by EDSS score (p<0·0001), neurological rating scale score (p=0·0001), paced auditory serial addition test (p=0·014), 25-foot walk (p<0·0001), and quality of life, as measured with the short form-36 (SF-36) questionnaire (p<0·0001).
Outpatient endovascular treatment of CCSVI was feasible, with a minor and negligible complication rate. Postoperative venous pressure was significantly lower in the IJVs and AZY (P < .001). The risk of restenosis was higher in the IJVs compared with the AZY (patency rate: IJV, 53%; AZY, 96%; odds ratio, 16; 95% confidence interval, 3.5-72.5; P < .0001). CCSVI endovascular treatment significantly improved MS clinical outcome measures, especially in the RR group: the rate of relapse-free patients changed from 27% to 50% postoperatively (P < .001) and of MR Gad+ lesions from 50% to 12% (P < .0001). The Multiple Sclerosis Functional Composite at 1 year improved significantly in RR patients (P < .008) but not in PP or SP. Physical QOL improved significantly in RR (P < .01) and in PP patients (P < .03), with a positive trend in SP (P < .08). Mental QOL showed significant improvement in RR (P < .003) and in PP (P < .01), but not in SP.
masci wrote:I'm trying to understand one thing. MS is linked to immune system cells that are activated to remove the deposited iron deposits in the brain because of CCSVI. Once we restore a normal venous outflow, how do we "turn off" the cells of the immune system?
adaptivemind wrote:Jagular, with all due respect, you are confusing the 'facts'. So here they are: 1. HSCT fatality rate is currently 0.84%, period, full stop, 2. HSCT cure rate as defined by ZERO disease progression post procedure (there already are patients who show no disease return up to 10 years post HSCT) is well above 80% (depending on whether RE or SP). And one last point, HSCT is in phase III of a large scale randomized trial
So back to the original question, "how to turn off an Immune system?" As things stand now, I would not pin my hopes on "liberations and/or worms". But then again, in the final anqlysis we are all free to decide what we choose to believe.
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