This Is MS Multiple Sclerosis Community: Knowledge & Support

Interesting how all 3 environmental factors involve the endothelium.
EBV and smoking are known endothelial dysrupters, in that they both change nitric oxide distribution in the blood vessel lining. And irritable bowel has been linked to endothelial dysfunction via leukocyte migration.
http://www.hopkinsguides.com/hopkins/ub ... l_disease_

The connection to heart disease also points to the vasculature and the endothelium....
very interesting connections from BNAC.
cheer

_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS

Here's the complete paper:
www.bnac.net/wp-content/uploads/2011/12 ... ntrols.pdf

For those wondering about the weak protective effect from supplements, did he say in his NY symposium presentation that gingko biloba was the supplement that was best?

BNAC also presented this research as a poster at ECTRIMS 2011. If you are interested in seeing the poster click here.

Right...gingko was the specific supplement mentioned by BNAC, for its anti thrombic, endothelial enhancing capabilities...but there are other great flavonoids (quercetin, bromelain, EGCG) This is from the paper.
‎
here's the thread on flavonoids...
chronic-cerebrospinal-venous-insufficiency-ccsvi-f40/topic17794.html

cheer

_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS

Here's an excellent regimen for endothelial health....

https://www.facebook.com/note.php?note_id=123456602210

It's ironic, now that I'm feeling better since venoplasty, I find it easier to manage a supplement regimen.

ok, consider me slow on the uptake....

This was a study done on the healthy controls only. No MS patients with CCSVI were included. We have a long-standing question: how healthy are the healthy controls? We don't yet have an answer on that, but now that we know those healthy controls with CCSVI are more likely to have had mono, more likely to have a history of smoking, and more likely to have irritable bowel syndrome. There is plenty of research on these risk factors in MS, but this is the first research on these as risk factors in CCSVI in healthy controls without MS.

What term can replace the term 'healthy control'? It seems to me we have healthy controls with neither MS nor CCSVI; patients with CCSVI but not MS; patients with MS but not CCSVI; and patients with MS and CCSVI. If CCSVI is a syndrome in its own right, I can't consider people with CCSVI without MS to be healthy controls.

Especially if they are blood relatives of someone with MS...as 33% of BNAC's "healthy normal controls" were.
Hope these people get followup, and watch their health.
In this case, the term "healthy control" means they simply do not have MS...yet.

At the Bologna conference in 2009, Dr. Zivadinov spoke before our dinner and told a (purely anecdotal) story about a "healthy normal" in their control group. She was a daughter of a woman with MS, who had CCSVI--
Here are my notes from that presentation--



How many "healthy normals" who tested positive for CCSVI went on to develop MS?

cheer

_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS

I am beginning to see that we need to have an accurate dx first, yes we have malformations and other risk factors yet we often don't have a dx that would stand up in court!
There are thousands of us that have symptoms that cross into all sorts of disease and to expect PTA or Diet, exercise and mind management to improve an unknown cause is, well I'll let you find your own words.

A classic example is how I am now looking Chiari Type One Malformations (http://chiarione.org/symptoms.html) as the possible cause for my health issues and yes the package of PTA, Diet, exercise and mind management will support working with a dx of CM1.

My point is that we need Neurology to up skill and have dx's that will withstand the scrutiny and give us accurate outcomes for all and any of these treatments we are using!

Here we are wondering why the PTA outcomes are so varied, it is actually that the dx of the de-generative type is too loose!

And the cross over of diseases with a vascular component is yet to be understood and accepted.

Go BNAC!

Regards Nigel