Risk factors for CCSVI are similar to risk factors for MS

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Risk factors for CCSVI are similar to risk factors for MS

Postby Cece » Wed Nov 30, 2011 4:43 pm

http://www.eurekalert.org/pub_releases/ ... 113011.php

Risk Factors for CCSVI are Similar to Risk Factors for Developing MS, UB Study Shows

Summary:

•A vascular condition called chronic cerebrospinal venous insufficiency (CCSVI), which has attracted global attention as possibly being correlated with MS has, for the first time, been studied for the presence of risk factors in subjects who do not have a neurological disease.
•A preliminary University at Buffalo study of 252 volunteers has found an association between CCSVI and as many as three characteristics widely viewed as possible or confirmed MS risk factors. They are: infectious mononucleosis, irritable bowel syndrome and smoking.
•The UB researchers conclude that the association of CCSVI risk factors with MS risk factors in subjects without known central nervous system disease is significant and warrants further study.

According to the results, individuals with CCSVI were 2.7 times more likely than individuals without CCSVI to have infectious mononucleosis, 3.9 times more likely to have irritable bowel syndrome and 1.98 times more likely to have a history of smoking.
In addition, individuals with heart disease -- which is not a known MS risk factor -- were 2.7 times more likely to have CCSVI, and those with heart murmurs, in particular, were 4.9 times more likely to have CCSVI. Zivadinov added that the study's finding of a weak, protective effect from the use of dietary supplements was also noted and has to be further explored.
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Re: Risk factors for CCSVI are similar to risk factors for M

Postby cheerleader » Wed Nov 30, 2011 6:17 pm

Interesting how all 3 environmental factors involve the endothelium.
EBV and smoking are known endothelial dysrupters, in that they both change nitric oxide distribution in the blood vessel lining. And irritable bowel has been linked to endothelial dysfunction via leukocyte migration.
http://www.hopkinsguides.com/hopkins/ub ... l_disease_

The connection to heart disease also points to the vasculature and the endothelium....
very interesting connections from BNAC.
cheer
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Re: Risk factors for CCSVI are similar to risk factors for M

Postby Cece » Thu Dec 01, 2011 10:22 am

Here's the complete paper:
www.bnac.net/wp-content/uploads/2011/12 ... ntrols.pdf

For those wondering about the weak protective effect from supplements, did he say in his NY symposium presentation that gingko biloba was the supplement that was best?
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Re: Risk factors for CCSVI are similar to risk factors for M

Postby prairie » Thu Dec 01, 2011 10:28 am

BNAC also presented this research as a poster at ECTRIMS 2011. If you are interested in seeing the poster click here.
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Re: Risk factors for CCSVI are similar to risk factors for M

Postby cheerleader » Thu Dec 01, 2011 10:38 am

Cece wrote:Here's the complete paper:
http://www.bnac.net/wp-content/uploads/ ... ntrols.pdf

For those wondering about the weak protective effect from supplements, did he say in his NY symposium presentation that gingko biloba was the supplement that was best?


Right...gingko was the specific supplement mentioned by BNAC, for its anti thrombic, endothelial enhancing capabilities...but there are other great flavonoids (quercetin, bromelain, EGCG) This is from the paper.
Among protective factors, we found that everyday use of dietary supplements showed a trend for lower frequency of CCSVI. Dietary supplements are widely used for improving the integrity and function of veins in the lower limbs, in order to increase the integrity of the tissue to improve the vein’s function [47]. They also decrease the capillary’s permeability by reducing the number and size of pores in the capillary’s walls, improve the tone of or dilate the blood vessels and affect blood-clotting mechanisms [47].

here's the thread on flavonoids...
chronic-cerebrospinal-venous-insufficiency-ccsvi-f40/topic17794.html

cheer
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Re: Risk factors for CCSVI are similar to risk factors for M

Postby Cece » Thu Dec 01, 2011 11:35 am

Here's an excellent regimen for endothelial health.... :)

https://www.facebook.com/note.php?note_id=123456602210

It's ironic, now that I'm feeling better since venoplasty, I find it easier to manage a supplement regimen.
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Re: Risk factors for CCSVI are similar to risk factors for M

Postby Cece » Sun Dec 04, 2011 9:07 am

ok, consider me slow on the uptake....

This was a study done on the healthy controls only. No MS patients with CCSVI were included. We have a long-standing question: how healthy are the healthy controls? We don't yet have an answer on that, but now that we know those healthy controls with CCSVI are more likely to have had mono, more likely to have a history of smoking, and more likely to have irritable bowel syndrome. There is plenty of research on these risk factors in MS, but this is the first research on these as risk factors in CCSVI in healthy controls without MS.

What term can replace the term 'healthy control'? It seems to me we have healthy controls with neither MS nor CCSVI; patients with CCSVI but not MS; patients with MS but not CCSVI; and patients with MS and CCSVI. If CCSVI is a syndrome in its own right, I can't consider people with CCSVI without MS to be healthy controls.
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Re: Risk factors for CCSVI are similar to risk factors for M

Postby cheerleader » Sun Dec 04, 2011 9:35 pm

Cece wrote:If CCSVI is a syndrome in its own right, I can't consider people with CCSVI without MS to be healthy controls.


Especially if they are blood relatives of someone with MS...as 33% of BNAC's "healthy normal controls" were.
Hope these people get followup, and watch their health.
In this case, the term "healthy control" means they simply do not have MS...yet.

At the Bologna conference in 2009, Dr. Zivadinov spoke before our dinner and told a (purely anecdotal) story about a "healthy normal" in their control group. She was a daughter of a woman with MS, who had CCSVI--
Here are my notes from that presentation--

Dr. Zivadinov states that they had tested a 25 year old girl who had come into Jacobs as a control. A healthy girl, who presented with bilateral jugular occlusion. Months later, she had her first CIS attack of MS, and an MRI was done to show two lesions. She also has a familial history of MS. He reiterated that all of the doppler testing was blinded, yet it corraborated CCSVI in MS 100%.


How many "healthy normals" who tested positive for CCSVI went on to develop MS?

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Husband dx RRMS 3/07
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http://ccsviinms.blogspot.com
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Re: Risk factors for CCSVI are similar to risk factors for M

Postby NZer1 » Sun Dec 04, 2011 10:56 pm

I am beginning to see that we need to have an accurate dx first, yes we have malformations and other risk factors yet we often don't have a dx that would stand up in court!
There are thousands of us that have symptoms that cross into all sorts of disease and to expect PTA or Diet, exercise and mind management to improve an unknown cause is, well I'll let you find your own words.

A classic example is how I am now looking Chiari Type One Malformations (http://chiarione.org/symptoms.html) as the possible cause for my health issues and yes the package of PTA, Diet, exercise and mind management will support working with a dx of CM1.

My point is that we need Neurology to up skill and have dx's that will withstand the scrutiny and give us accurate outcomes for all and any of these treatments we are using!

Here we are wondering why the PTA outcomes are so varied, it is actually that the dx of the de-generative type is too loose!

And the cross over of diseases with a vascular component is yet to be understood and accepted.

Go BNAC!

Regards Nigel
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