However, in autopsy tissues of MS patients, lesions in the cerebral cortex show demyelination without inflammation, raising a challenging issue: if cortical lesions form entirely without inflammation, then cortical demyelination would not be explainable by current theories of MS nor treatable by current MS therapies.
MrSuccess wrote:Also known as Trauma ..... from the OUTSIDE >>>>> to the INSIDE.
So the apple bruise starts with an external blow ? Who would have guessed ?
"The next step in this research is to study the lesions to uncover new molecular targets for treatment. We also need to push forward to develop imaging techniques to view these cortical lesions," said Dr. Lucchinetti. "In that way, effects of treatment can more easily be measured."
Using cortical tissue obtained during brain biopsy for other reasons, researchers found that cortical lesions were "frequent, inflammatory, and strongly associated with meningeal inflammation."
"Our study shows the cortex is involved early in MS," Claudia F. Lucchinetti, MD, co-lead author of the study and a neurologist at the Mayo Clinic College of Medicine, Rochester, Minnesota, told Medscape Medical News. "The cortex in some cases may even be the initial target."
marcstck wrote:The question of from whence the observed inflammation arises still has not been answered, but inflammation is an indicator of immune activity, so immunomodulating drugs would still have some effect, as has been seen over the last 15 years or so. Let's not lose sight of the fact that extreme immunosuppression (à la HSCT, or Campath therapy) shows a dramatic degree of decrease in disease activity. Not saying the autoimmune model of the disease is correct, but this particular research doesn't put a stake in its heart . . .
Cece wrote:There is a general discussion forum?????
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