They both have a permeable endothelium and endothelial dysfunction.
That's why tysabri has been used in Crohn's, it is supposed to decrease permeability and leukocyte migration.
But it's an awfully risky drug to do that.http://www.nature.com/labinvest/journal ... 1122a.html
You do not need an errant immune system to create endothelial dysfunction.
All you need is hypoxia, slowed or disturbed blood flow. That's enough to change the permeability of the lining, and allow the immune system access into tissue.
I get nervous when I see some researchers trying to bring this back to the autoimmune theory without investigating the other mechanisms of endothelial dysfunction.
Glad John Cooke and J. Steven Alexander spoke at the conference.