I'm separating out the doctors into different threads because there is just so much information coming in.
!!! A difference between the healthy controls with CCSVI and the MS patients with CCSVI. But what does it mean? If our veins are further apart, is there more brain tissue relying on each vein? Or is it that the healthy patients with CCSVI responded with angiogenesis, making newer veins closer together to compensate for the dysfunction in outflow, and patients with MS did not compensate in this way?Dr. Zivadinov: The veins of MS patients with CCSVI are significantly further apart than healthy controls with CCSVI
Dr. Zivadinov: Lesions are localized b/c cerebral blood flow is compromised locally; otherwise lesions would be everywhere
Dr. Zivadinov: Extracranial collatoral circulation has developed to manage the deficiencies of the jugular outflow
Robert Zivadinov: CCSVI does exist & is not unique to MS & is present in other neurological & non-neurological diseases & healthy controls.
Dr. Zivadinov: MS patients have about 20% decreased venous volume i terms of all the vasculature of the brain
Dr. Zivadinov: Lower cerebrospinal flow is linked to MS deveopment and progression
Dr. Zivadinov: CCSVI is as prevalent in other neurological diseases as it is in MS (50-60% of all patients blind tested)
Dr. Zivadinov: Irritable bowel syndrome is a consequence of CCSVI
Dr. Zivadinov: Not clear if iron is primary or secondary to MS, but iron levels closely related to degree of inflammation
Dr. Zivadinov: "ideal modality is multi-modal imaging to increase confidence that a stenosis is there."
Dr. Zivadinov: Nothing can stop scientific curiosity
Dr. Zivadinov: Perfusion damage & oxidative stress are a result of decreased capillary bed blood flow