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The effects of jugular venous reflux in aging (Chih-Ping Chung, TAIWAN)

Decreased cerebral perfusion and increased cerebral white matter changes have been found in the elderly.
These age-related cerebral hypoperfusion would result in dementia, gait disturbance, and disables. However, its
pathophysiologies have not elucidated yet. The internal jugular venous hemodynamic profiles in our
ultrasonographic registry suggest an increase in internal jugular venous outflow impedance with aging. We
proposed the hypothesis that jugular venous reflux plays a role in age-related white matter changes. In the
present talk, I will provide data suggesting that retrogradely-transmitted venous pressure of jugular venous
reflux could reach cerebral venous system and influent cerebral blood flow in our clinical Doppler
ultrasonographic studies. The results of studying the relationship between jugular venous reflux and agerelated
white matter changes will also be demonstrated. At last, I will talk about some preliminary data about
our animal model of jugular venous reflux.