http://www.ccsvi.org/index.php/helping- ... ial-health
During their research, Furchgott and Ignarro independently discovered that the healthy endothelium secretes substances which protect vascular health. Chief among these is nitric-oxide, a tiny two-atom gas, which is now considered the hallmark of normal endothelial function and the elusive “signaling factor” they had been searching for.
Then i come across this article in PDF format on Dimethylfumarate, or the new oral medication called BG-12
which my wife's neuro wants to put her on next year when it's available.
Microglia are distributed throughout the CNS as a network of resting immunocompetent cells derived from the monocyte/ macrophage lineage. The cells become rapidly activated in response to injury or in the presence of pathogens and - like other tissue macrophages in the first line of host defense - play a pivotal role as phagocytic, antigen-presenting cells. However, it is also this efficient defensive action that makes them potentially neurotoxic cells. By releasing various kinds of noxious factors such as proinflammatory cytokines (i.e. TNF-?, IL-1?, IL-6) or proinflammatory molecules like nitric oxide (NO) microglia may potentiate damage to CNS cells [10-12]. IL-1?  and NO  are expressed in chronic active plaques in MS patients. NO reacts with superoxide anion to generate peroxynitrite, a highly reactive molecule capable of oxidizing proteins, lipids and DNA; and which mediates microglial toxicity to oligodendrocytes  NO can trigger immune cascades that further enhance inflammatory- mediated CNS damage: Increased concentrations of NO can lead to enhanced expression of chemokine (C-CmotifCmotif) ligand 2 (CCL2) on astrocytes which, in turn, leads to infiltration of CD11b cells and additional tissue damage .
http://www.biomedcentral.com/content/pd ... 4-7-30.pdf
I don't get it..!!! Nitric Oxide can trigger immune cascades that further enhance inflammatory mediated CNS damage..????
And this article talks about how most neuro's will prescribe BG-12 to their patients..
So... am i missing something..????