Cece wrote:drsclafani wrote:Cece, they are talking about the nerves IN the wall of the artery, not on the vagus nerve. They did not look at the vagus itself.
I was trying to decode this: "Vasovagal Therapy- delivery of physical energy to periadventitial autonomic fibers. Not vagal compression"
I thought periadventitial autonomic fibers might mean the nerves within the outer layer of the blood vessel. These nerves within the blood vessel can be damaged by balloon angioplasty. The image above has them labelled as parasympathetic and sympathetic nerves, contained within the tunica adventitia. If they were damaged however it would be very localized. It's possible that I am trying to make sense of something that is nonsensical. I am very uncomfortable with the ballooning of nonobstructed jugulars.
Reading on his website, Synergy says: "We believe this is due to the stimulation of the vagus nerve that generally occurs during the CCSVI procedure."
I understand your reasoning. However in the quote paper, they are referring to nerve fibers in the wall of the artery, although there are autonomic fibers in the wall of the vein as well.
cece, look up renal sympathectomy by ablation of autonomic fibers embedded in the wall of the renal artery as a treatment for essential hypertension. This work is something I do on a randomized trial. In our study this treatment is indicated for uncontrolled hypertension (greater than 160 mm systolic) despite maximum tolerable doses of at least three classes of antihypertensive medications.
There is a distinct feedback between the autonomic fibers in the renal artery and the brain stem that goes awry in essential hypertension. Ablating the fibers by application of radiofrequency derived thermal energy heating the wall of the artery to about 125 degrees fahrenheit damages irrevocably these nerves, cuts the feedback mechanism, causes loss of autonomic overdrive and reduces hypertension an average of 25 points systolic.
If angioplasty actually disrupted autonomic nerve function in jugular veins, would it not have similar effect on renal artery autonomic nerves? Yet angioplasty of renal arteries has not been shown to be of value in patients with essential hypertension. True ablation of these autonomic fibers is required to affect the autonomic function.