Evidence of microbleeds was detected in 28 of the patients. These patients had significantly more white matter hyperintensities in the MRI scans (mean score 10.5 versus 7 among those with no microbleeds, P=0.001), and there were trends in the microbleed patients toward more large-vessel and lacunar infarcts.
Why would patients with microbleeds have more white matter hyperintensities? This is in patients with Alzheimer's disease. In CCSVI there is suspected to be diapedesis or leakage of red blood cells into the brain. Is this similar to a microbleed? If microbleeds contribute to the formation of a white matter hyperintensity in Alzheimer's disease, it would lend support to the idea that diapedesis in CCSVI contributes to the formation of our white matter lesions.