exercise in the month after angioplasty

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

exercise in the month after angioplasty

Postby Cece » Wed Oct 03, 2012 1:48 pm

Physical Training Increases Endothelial Progenitor Cells, Inhibits Neointima Formation, and Enhances Angiogenesis

Ulrich Laufs, MD; Nikos Werner, MD; Andreas Link, MD; Matthias Endres, MD; Sven Wassmann, MD; Kristina Jürgens, MD; Eckart Miche, MD; Michael Böhm, MD; Georg Nickenig, MD

Background— The molecular mechanisms by which physical training improves peripheral and coronary artery disease are poorly understood. Bone marrow–derived endothelial progenitor cells (EPCs) are thought to exert beneficial effects on atherosclerosis, angiogenesis, and vascular repair.

Methods and Results— To study the effect of physical activity on the bone marrow, EPCs were quantified by fluorescence-activated cell sorter analysis in mice randomized to running wheels (5.1±0.8 km/d, n=12 to 16 per group) or no running wheel. Numbers of EPCs circulating in the peripheral blood of trained mice were enhanced to 267±19%, 289±22%, and 280±25% of control levels after 7, 14, and 28 days, respectively, accompanied by a similar increase of EPCs in the bone marrow and EPCs expanded from spleen-derived mononuclear cells. eNOS−/− mice and wild-type mice treated with NG-nitro-L-arginine methyl ester showed lower EPC numbers at baseline and a significantly attenuated increase of EPC in response to physical activity. Exercise NO dependently increased serum levels of vascular endothelial growth factor and reduced the rate of apoptosis in spleen-derived EPCs. Running inhibited neointima formation after carotid artery injury by 22±2%. Neoangiogenesis, as assessed in a subcutaneous disc model, was increased by 41±16% compared with controls. In patients with stable coronary artery disease (n=19), moderate exercise training for 28 days led to a significant increase in circulating EPCs and reduced EPC apoptosis.

Conclusions— Physical activity increases the production and circulating numbers of EPCs via a partially NO-dependent, antiapoptotic effect that could potentially underlie exercise-related beneficial effects on cardiovascular diseases.

Running is cheaper than stem cells. It inhibits neointima formation by 22% after carotid injury in mice. Angioplasty results in a form of injury to the jugular or azygous vein. Reduction of neotintima formation is what stem cells also do, but I do not know by what percentage.
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Re: exercise in the month after angioplasty

Postby 1eye » Thu Oct 04, 2012 11:08 am

Cece wrote:Running is cheaper than stem cells.
Last time I ran was about 2001. Gave up, then. I have since then dreamed about running, though there is little danger of that now, since I hardly dream at all. I try to exercise as much as I can, including aerobics. There is a sort of recumbent elliptical machine called a nustep, and if I bungee my dropped foot onto the pedal, I can step for about 20-30 minutes. They're hard to find but some gyms and seniors homes have them. Will that help with angiogenesis? The other gizmo I find useful is clip-on pedals on my tricycle. Heat being a problem, I purchased clip-on sandals, and that's what holds my dropped-foot on. I can do 5-10 Kanadian Miles (KM -- quite a bit shorter than the American ones) on the tricycle. I think because it's so much fun, and the air rushing past cools me off, I can last nearly twice as long. Your kilometerage may vary.
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