Amiloride: crosspost from /general-discussion

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Amiloride: crosspost from /general-discussion

Postby daniel » Sat Feb 09, 2013 10:15 am

thread by bromley: general-discussion-f1/topic4714.html

NIH pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23365093

Blood pressure drug hope for Multiple Sclerosis 12 November 2007
A drug which has been used for decades to treat high blood pressure may turn out to be a key treatment for multiple sclerosis, say British researchers.

Amiloride was found to reduce degeneration of nerve tissue in mice and the team at Oxford University are now planning a trial in MS patients.

It works by blocking the build up of high levels of calcium in nerve cells, which can lead to nerve damage.

There are about 85,000 people with MS in the UK.

The condition is caused by a defect in the body's immune system, which turns in on itself, and attacks the fatty myelin sheath which coats the nerves.

This damage to nerve cells is caused in part by a build up of calcium.

Professor Lars Fugger and colleagues investigated the effects of a specific channel, ASIC1, which controls the entry of calcium molecules into cells.

In mice with a condition that mimics MS, they found that when the channel remains open, calcium can flood into nerve cells in higher than normal proportions and cause damage.

Inflammation like that found in MS leads to acidic conditions, which would lead to the channel opening and too much calcium accumulating in nerve cells, Professor Fugger said.

Treatment

Amiloride, a drug used for many years to treat high blood pressure and heart failure, was found to stop calcium entering through the ASIC1 channel and prevent degeneration of nerve tissue in mice, the journal Nature Medicine reported.

Professor Fugger from the Medical Research Council Human Immunology Unit said the fact the drug was already licensed would speed up the process of getting the treatment to patients should it be prove effective.

He is currently working out what the appropriate dose would be in humans and plans to start a clinical trial next year.

"To develop a drug from scratch takes 10-15 years and a billion dollars and some of them are abruptly halted by unexpected side effects," he said.

"It was known that calcium is not good for nerve cells but it's not been appreciated how simple it is to block it."

Dr Laura Bell, from the MS Society, said: "Protection of nerve fibres is a promising and vital area of research and this is why the MS Society is currently spending half a million pounds on a clinical trial investigating this type of nerve protection in people with MS.

"The early stage results from Oxford are interesting and we look forward to seeing the findings of future studies."

The research is published in Nature Medicine.

Source BBC News © BBC 2007 (12/11/07)
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Re: Amiloride: crosspost from /general-discussion

Postby Cece » Sat Feb 09, 2013 1:21 pm

If there is any hypertension effect in CCSVI, the antihypertensive could help in that regard?
It's crazy how many drugs are in development for MS. So much research and money poured into it. So few effective treatment in return!
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Re: Amiloride: crosspost from /general-discussion

Postby Daisy3 » Sat Feb 09, 2013 1:34 pm

The first real positive thing I have seen for PPMS.
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Re: Amiloride: crosspost from /general-discussion

Postby Cece » Sat Feb 09, 2013 1:55 pm

Daisy3, have you read about anti-lingo-1? It's in the research stages but it might work for progressive. Fingers crossed.
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Re: Amiloride: crosspost from /general-discussion

Postby 1eye » Sat Feb 09, 2013 2:12 pm

If it's classed with drugs indicated for "MS" the price for that indication will be extremely high, and there will be variants concocted specially only for that, so they can be patented. The result will be that drug vendors will be even more likely to use this kind of usurious re-branding of out-of-patent products, and the clinical trials and "studies" that they use to justify it. All that is really required is for GPs to prescribe it, off-label, to "MS" patients. I am already taking BP medication for my heart.
"Try - Just A Little Bit Harder" - Janis Joplin
CCSVI procedure Albany Aug 2010
'MS' is over - if you want it
Patients sans/without patience
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Re: Amiloride: crosspost from /general-discussion

Postby daniel » Sat Feb 09, 2013 2:55 pm

another related thread in /drug pipelines: drug-pipeline-f13/topic21614.html
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Re: Amiloride: crosspost from /general-discussion

Postby Daisy3 » Mon Feb 11, 2013 2:45 pm

Cece wrote:Daisy3, have you read about anti-lingo-1? It's in the research stages but it might work for progressive. Fingers crossed.



Hi Cece,

How are you?! I read about anti-lingo-1 a while ago and could not find anything on the PPMS side.
I will have another look,it can't hurt.
I also thought it was going to take a number of years before the drug was ready?
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